"NFATC1" Related Products


Recombinant Human Nuclear Factor Of Activated T-cells, Cytoplasmic, Calcineurin-Dependent 1, His-tagged

Cat. No. : NFATC1-1274H
Product Overview : Recombinant humanNFATC1 contains amino acids 2-298 and N-terminal polyhistidine tag.
Description : NFATC1 is a member of the NFATfamily of proteins which are Ca2+/calcineurin-responsivetranscription factors primarily recognized for their central roles in Tlymphocyte activation and cardiac valve development. NFAT consists of atleast two components: a preexisting cytosolic component that translocates tothe nucleus upon T-cell receptor (TCR) stimulation, and an inducible nuclearcomponent.
Source : E. coli
Species : Human
Form : Carrier-free liquid.
Molecular Weight : 35 kDa(migrates at ~ 48 kDa on SDS-PAGE gel)
Purity : 95% asdetermined by SDS-PAGE analysis
Biological Activity : Recombinanthuman NFATC1 is phosphorylatable in vitro,using recombinant GSK3 and PKA. Optimization of the cell stimulationprotocol, cell lysis procedure, and reaction conditions may be required foreach specific application.
storage : Store at2-4°C for short term storage. Stable for 1 year in working aliquots at -20°C.Avoid repeated freeze-thaw cycles.
OfficialSymbol : NFATC1
Pathways : Axon guidance; B cell receptorsignaling pathway; Natural killer cell mediated cytotoxicity; T cell receptorsignaling pathway; VEGF signaling pathway; Wnt signaling pathway
PDB rendering basedon 1a66. :

Gene Name : NFATC1 nuclear factor ofactivated T-cells, cytoplasmic, calcineurin-dependent 1 [ Homo sapiens]
Synonyms : NFATC1; nuclear factor ofactivated T-cells, cytoplasmic, calcineurin-dependent 1; NFAT2; NFATc; NF-ATC;MGC138448; NFAT transcription complex cytosolic component; Nuclear factor ofactivated T-cells, cytoplasmic 1; NF-ATc1; NFATC; NFAT transcription complexcytosolic component
Gene ID : 4772
mRNA Refseq : NM_006162
Protein Refseq : NP_006153
MIM : 600489
UniProt ID : O95644
Chromosome Location : 18q23
Function : FK506 binding; promoter binding;protein binding; transcription activator activity; transcription factoractivity

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