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Recombinant Human VEGFA

Cat.No. : VEGFA-P1003H
Product Overview : Recombinant human VEGFA fused with6His was produced in CHO cells.
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  • Gene Information
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Cat. No. : VEGFA-P1003H
Description : Vascularendothelial growth factor (VEGFA) is a mitogen that specifically acts onendo- thelial cells and has various effects, including mediating increasedvascular permeability and inducing angiogenesis , cell growth, migration, andinhibition of apoptosis. It is a pivotal stimulator of angiogenesis becauseits binding to VEGF receptors has been shown to promote endothelial cellmigration and proliferation, two key features required for the development ofnew blood vessels. In addition, VEGF-A increases vascular permeability, whichmay also contribute to angiogenesis and tumor growth. Recognition of thecentral role of VEGF-A in angiogenesis has led to the hypothesis that itsinhibition may represent a novel and effective approach to the treatment ofcancer and other conditions characterized by pathologic angiogenesis.
ProteinConstruction : Recombinanthuman VEGFA is combined the Sequence of VEFGA with 6His.
Source : ChineseHamster Ovary (CHO cell)
Purity : >95%as determined by SDS-PAGE and HPLC
Endotoxin : <1.0EU per 10 mg protein as determined by the LAL method
Stability : Samplesare stable for up to six months from date of receipt at -20℃ and are stable fortwo months at 4℃.
Molecular Mass : Recombinanthuman VEGFA comprises 342 amino acid residues, combining 6His, The MW is25kDa under reducing conditions.
Predicted N terminal : APMAEGGGQN
Formulation : Normally20-50mM NaAC-HAC and 100-150 mM NaCl are added, pH 5.0-6.0.
Storage : Store itunder sterile conditions at -70℃upon receiving. Recommend to pack the protein intosmaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : VEGFA vascular endothelial growth factor A [ Homo sapiens ]
Official Symbol : VEGFA
Synonyms : VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1;VEGF-A; MGC70609; vascular permeability factor; vascular endothelial growthfactor isoform VEGF165; vascular endothelial growth factor
Gene ID : 7422
mRNA Refseq : NM_001025366
Protein Refseq : NP_001020537
MIM : 192240
UniProt ID : P15692
Chromosome Location : 6p12
Pathway : Cytokine-cytokinereceptor interaction; Focal adhesion; Pancreatic cancer; Renal cellcarcinoma; VEGF signaling pathway; mTOR signaling pathway; Hemostasis;Signaling by VEGF
Function : cellsurface binding; chemoattractant activity; cytokine activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How does VEGFA protein relate to other biomarkers? 05/28/2022

Studies have shown that there is an association between the expression level of VEGFA protein and other biomarkers, for example, it can be associated with indicators such as tumor cell differentiation, metastatic capacity, and prognosis.

How to harness the activity of VEGFA protein for disease treatment? 05/14/2022

At present, a variety of drugs have been developed to target the VEGFA protein and its related signaling pathway, including inhibiting its expression and inhibiting its binding to receptors, etc., for the treatment of tumors and other vascular-related diseases.

What is the role of VEGFA protein in tumor angiogenesis? 09/24/2020

VEGFA protein plays a key role in tumor angiogenesis, promoting tumor growth and metastasis by stimulating endothelial cell proliferation, migration, and vascular network formation.

How well is the VEGFA protein expressed in different tissues and organs? 07/09/2020

The expression of VEGFA protein in different tissues and organs is different, and it is expressed in tumor tissue, cardiovascular system and other tissues and organs, and the expression level may be affected by many factors.

What is the relationship between the expression level of VEGFA protein and the degree of tumor malignancy? 03/26/2020

Studies have shown that the expression level of VEGFA protein is related to the degree of malignancy of the tumor, and the high expression of VEGFA protein often indicates that the tumor is more aggressive.

How about the fuction of VEGFA protein in cardiovascular disease? 01/10/2019

VEGFA protein plays an important role in cardiovascular disease by regulating endothelial cell function, promoting vascular repair and maintaining cardiovascular system homeostasis.

Customer Reviews (2)

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Reviews
04/21/2021

    VEGFA's catalytic activity is so strong that it can adapt even in the face of complex chemical reactions.

    03/09/2020

      VEGFA they produced was highly active and the experimental effect was obvious.

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