| Cat. No.: | CABT-P1009H |
| Product Overview: | Recombinant monoclonal antibody to Human RANKL. |
| Antigen Description: | Cytokine that binds to TNFRSF11B/OPG and toTNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augmentsthe ability of dendritic cells to stimulate naive T-cell proliferation. Maybe an important regulator of interactions between T-cells and dendritic cellsand may play a role in the regulation of the T-cell-dependent immuneresponse. May also play an important role in enhanced bone-resorption inhumoral hypercalcemia of malignancy. |
| Protein Costruction: | DNAsequences coding OPGL antibody heavy and light chains cotransfected to hostcell were expressed with a human Igκ signal in light chain. |
| Isotype: | IgG2 |
| Formulation: | Normally 1mg/mlL-His, 1mg/ml Sucrose and 0.04 mg/ml Tween-80 are added, pH 6.0. Pleasecontact us for any concerns or special requirements. |
| Purity Detail: | >95% asdetermined by SDS-PAGE and HPLC |
| Source: | CultureSupernatant |
| Expression Host: | Chinese HamsterOvary (CHO cell) |
| Endotoxin: | <1.0EUper 10 mg protein as determined by the LAL method |
| Molecular Mass: | The secreted recombinant Monoclonal antibody to human RANKL comprises 1326 amino acids. As a result ofglycosylation, it has molecular mass of 150kDa in SDS-PAGE under non-reducingconditions. |
| Predicted N terminal: | Hchain: EVQLLESGGG;Lchain:EIVLTQSPGT |
| Stability: | Samples are stablefor up to twelve months from date of receipt at -20°C and are stable forsix months at 4°C. |
| Storage: | Store it understerile conditions at -70°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage. |
| Background: | The monoclonal antibody to RANKL is a human IgG2 monoclonal antibody, have affinity andspecificity with human RANKL (receptor activator of nuclear factor kappa-Bligand). 147 kDa Molecular weight, is genetically engineered mammalian(Chinese hamster ovary) cell production. |
| Gene Name: | TNFSF11 tumor necrosisfactor (ligand) superfamily, member 11 [ Homo sapiens ] |
| Official Symbol: | TNFSF11 |
| Synonyms: | ODF; OPGL; sOdf; CD254; OPTB2; RANKL;TRANCE; hRANKL2 ; Osteoclast differentiation factorantibody; Osteoprotegerin ligand antibody; Receptor activator of nuclearfactor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand;sOdf antibody; SOFA antibodyTNF related activation induced cytokineantibody; TNF11_HUMAN; TNFSF 11 antibody; TRANCE; Tumor necrosis factor(ligand) superfamily member 11; Tumor necrosis factor ligand superfamilymember 11; soluble form antibody interleukin-12 subunit beta; interleukin-12 subunit beta |
| Gene ID: | 8600 |
| mRNA Refseq: | NM_003701.3 |
| Protein Refseq: | NP_003692.1 |
| MIM: | 602642 |
| UniProt ID: | Q5T9Y4 |
| Chromosome Location: | 13q14 |
| Pathway: | Cytokine-cytokine receptor interaction; Cytokine-cytokinereceptor interaction; IL6-mediated signaling events; Osteoblast Signaling; Osteoclastdifferentiation; Rheumatoid arthritis |
| Function: | cytokine activity; receptoractivity; tumor necrosis factor receptor binding; tumor necrosis factorreceptor superfamily binding |
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