Recombinant Anti-Human RANKL Monoclonal Antibody CABT-P1009H

Recombinant Anti-Human RANKL Monoclonal Antibody

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Recombinant Anti-Human RANKL Monoclonal Antibody

TNFSF11 Related Products

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Cat. No. : CABT-P1009H
Product Overview : Recombinant monoclonal antibody to Human RANKL.
Antigen Description : Cytokine that binds to TNFRSF11B/OPG and toTNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augmentsthe ability of dendritic cells to stimulate naive T-cell proliferation. Maybe an important regulator of interactions between T-cells and dendritic cellsand may play a role in the regulation of the T-cell-dependent immuneresponse. May also play an important role in enhanced bone-resorption inhumoral hypercalcemia of malignancy.
Protein Costruction : DNAsequences coding OPGL antibody heavy and light chains cotransfected to hostcell were expressed with a human Igκ signal in light chain.
Isotype : IgG2
Formulation : Normally 1mg/mlL-His, 1mg/ml Sucrose and 0.04 mg/ml Tween-80 are added, pH 6.0. Pleasecontact us for any concerns or special requirements.
Purity Detail : >95% asdetermined by SDS-PAGE and HPLC
Source : CultureSupernatant
Expression Host : Chinese HamsterOvary (CHO cell)
Endotoxin : <1.0EUper 10 mg protein as determined by the LAL method
Molecular Mass : The secreted recombinant Monoclonal antibody to human RANKL comprises 1326 amino acids. As a result ofglycosylation, it has molecular mass of 150kDa in SDS-PAGE under non-reducingconditions.
Predicted N terminal : Hchain: EVQLLESGGG;Lchain:EIVLTQSPGT
Stability : Samples are stablefor up to twelve months from date of receipt at -20°C and are stable forsix months at 4°C.
Storage : Store it understerile conditions at -70°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background : The monoclonal antibody to RANKL is a human IgG2 monoclonal antibody, have affinity andspecificity with human RANKL (receptor activator of nuclear factor kappa-Bligand). 147 kDa Molecular weight, is genetically engineered mammalian(Chinese hamster ovary) cell production.
Gene Name : TNFSF11 tumor necrosisfactor (ligand) superfamily, member 11 [ Homo sapiens ]
Official Symbol : TNFSF11
Synonyms : ODF; OPGL; sOdf; CD254; OPTB2; RANKL;TRANCE; hRANKL2 ; Osteoclast differentiation factorantibody; Osteoprotegerin ligand antibody; Receptor activator of nuclearfactor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand;sOdf antibody; SOFA antibodyTNF related activation induced cytokineantibody; TNF11_HUMAN; TNFSF 11 antibody; TRANCE; Tumor necrosis factor(ligand) superfamily member 11; Tumor necrosis factor ligand superfamilymember 11; soluble form antibody interleukin-12 subunit beta; interleukin-12 subunit beta
Gene ID : 8600
mRNA Refseq : NM_003701.3
Protein Refseq : NP_003692.1
MIM : 602642
UniProt ID : Q5T9Y4
Chromosome Location : 13q14
Pathway : Cytokine-cytokine receptor interaction; Cytokine-cytokinereceptor interaction; IL6-mediated signaling events; Osteoblast Signaling; Osteoclastdifferentiation; Rheumatoid arthritis
Function : cytokine activity; receptoractivity; tumor necrosis factor receptor binding; tumor necrosis factorreceptor superfamily binding

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