Recombinant Anti-Human RANKL Monoclonal Antibody


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Recombinant Anti-Human RANKL Monoclonal Antibody

TNFSF11 Related Products

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Cat. No. : CABT-P1009H
Product Overview : Recombinant monoclonal antibody to Human RANKL.
Antigen Description : Cytokine that binds to TNFRSF11B/OPG and toTNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augmentsthe ability of dendritic cells to stimulate naive T-cell proliferation. Maybe an important regulator of interactions between T-cells and dendritic cellsand may play a role in the regulation of the T-cell-dependent immuneresponse. May also play an important role in enhanced bone-resorption inhumoral hypercalcemia of malignancy.
Protein Costruction : DNAsequences coding OPGL antibody heavy and light chains cotransfected to hostcell were expressed with a human Igκ signal in light chain.
Isotype : IgG2
Formulation : Normally 1mg/mlL-His, 1mg/ml Sucrose and 0.04 mg/ml Tween-80 are added, pH 6.0. Pleasecontact us for any concerns or special requirements.
Purity Detail : >95% asdetermined by SDS-PAGE and HPLC
Source : CultureSupernatant
Expression Host : Chinese HamsterOvary (CHO cell)
Endotoxin : <1.0EUper 10 mg protein as determined by the LAL method
Molecular Mass : The secreted recombinant Monoclonal antibody to human RANKL comprises 1326 amino acids. As a result ofglycosylation, it has molecular mass of 150kDa in SDS-PAGE under non-reducingconditions.
Predicted N terminal : Hchain: EVQLLESGGG;Lchain:EIVLTQSPGT
Stability : Samples are stablefor up to twelve months from date of receipt at -20°C and are stable forsix months at 4°C.
Storage : Store it understerile conditions at -70°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background : The monoclonal antibody to RANKL is a human IgG2 monoclonal antibody, have affinity andspecificity with human RANKL (receptor activator of nuclear factor kappa-Bligand). 147 kDa Molecular weight, is genetically engineered mammalian(Chinese hamster ovary) cell production.
Gene Name : TNFSF11 tumor necrosisfactor (ligand) superfamily, member 11 [ Homo sapiens ]
Official Symbol : TNFSF11
Synonyms : ODF; OPGL; sOdf; CD254; OPTB2; RANKL;TRANCE; hRANKL2 ; Osteoclast differentiation factorantibody; Osteoprotegerin ligand antibody; Receptor activator of nuclearfactor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand;sOdf antibody; SOFA antibodyTNF related activation induced cytokineantibody; TNF11_HUMAN; TNFSF 11 antibody; TRANCE; Tumor necrosis factor(ligand) superfamily member 11; Tumor necrosis factor ligand superfamilymember 11; soluble form antibody interleukin-12 subunit beta; interleukin-12 subunit beta
Gene ID : 8600
mRNA Refseq : NM_003701.3
Protein Refseq : NP_003692.1
MIM : 602642
UniProt ID : Q5T9Y4
Chromosome Location : 13q14
Pathway : Cytokine-cytokine receptor interaction; Cytokine-cytokinereceptor interaction; IL6-mediated signaling events; Osteoblast Signaling; Osteoclastdifferentiation; Rheumatoid arthritis
Function : cytokine activity; receptoractivity; tumor necrosis factor receptor binding; tumor necrosis factorreceptor superfamily binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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