Active Recombinant Human Hyaluronoglucosaminidase 4, His-tagged
Cat.No. : | HYAL4-1973H |
Product Overview : | RecombinantHuman HYAL4 protein was expressed in Chinese HamsterOvary cell line. Cys34-Pro462, with an N-terminal CD33signals sequence and a C-terminal 6-His tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | HYAL4-1973H |
Description : | Humanhyaluronidases (HYALs) are a group of five endoβ-N-acetyl-hexosaminidases thatinclude HYAL1, HYAL2, HYAL3, HYAL4, and SPAM1 (PH20). While HYAL1, HYAL2 andSPAM1 are endoβ-N-acetyl-glucosaminidase that are mainly active on hyaluronanwith little activity on chondroitin sulfate, HYAL4 is the only known endoβ-N-acetyl-galactosaminidasethat is mainly active on chondroitin sulfate (type C and D in particular)with no activity on hyaluronan. Hyaluronan and chondroitin sulfate areabundant extracellular matrix components that have numerous biologicalfunctions. |
Source : | Chinese HamsterOvary cell line, CHO-derived. |
Form : | Supplied as a 0.2 μmfiltered solution in Tris, NaCl and Glycerol. |
N-terminalSequence : | Cys34 |
MolecularWeight : | 49 kDa |
Activity : | Measuredby its ability to hydrolyze S-35 labeled bovine cartilage chondroitin sulfate< 500 ng of rhHYAL4 is required for the 50% hydrolysis of 10 μgchondroitin sulfate, as measured under the described conditions. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
SDS-PAGE : | 66-85kDa, reducing conditions. |
Purity : | >95%,by SDS-PAGE under reducing conditions and visualized by Colloidal CoomassieBlue stain at 5 ug per lane. |
Storage : | Use amanual defrost freezer and avoid repeated freezethaw cycles. 6 monthsfrom date of receipt, -20 to -70°C as supplied. 3 months,-20to-70°C under sterile conditions after opening. |
Gene Name : | HYAL4 hyaluronoglucosaminidase4 [ Homo sapiens ] |
Official Symbol : | HYAL4 |
Synonyms : | HYAL4;hyaluronoglucosaminidase 4; CSHY; hyaluronidase-4;hyal-4; hyaluronidase 4; hyaluronoglucosaminidase-4;chondroitin sulfate hydrolase; EC 3.2.1.35 |
Gene ID : | 23553 |
mRNA Refseq : | NM_012269 |
Protein Refseq : | NP_036401 |
MIM : | 604510 |
UniProt ID : | Q2M3T9 |
Chromosome Location : | 7q31.3 |
Pathway : | Chondroitin sulfate degradation; Dermatansulfate degradation; Glycosaminoglycan degradation; Metabolic pathways |
Function : | hyalurononglucosaminidaseactivity; hydrolase activity, acting on glycosyl bonds |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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