"GPC6" Related Products

Recombinant Human Glypican 6, His-tagged

Cat. No.: GPC6-5629H
Product Overview: RecombinantHuman GPC6 protein was expressed in Murine myeloma cell line. Asp24-Arg354& Ser355-Val527, with a C-terminal 6-His tag.
Description: The glypicans(glypiated proteoglycans) are a small multigene family of GPI-linkedproteoglycans that likely play a key role in embryonic morphogenesis. Thereare six known mammalian glypicans. They all share a common-sized protein coreof 60-70 kDa, an N-terminus which likely forms a compact globular domain, 14conserved cysteines that form multiple intrachain disulfide bonds, and anumber of C-terminal N-and O-linked carbohydrate attachment sites. Based onexon organization and the location of O-linked glycosylation sites, at leasttwo subfamilies of glypicans are known, with one subfamily containingglypicans-1, 2, 4, and 6, and another subfamily containing glypicans-3 and 5.
Source: Murine myeloma cellline, NS0-derived.
Form: Lyophilized from a0.2 um filtered solution in PBS.
N-terminalSequence: Asp24 & Ser355
MolecularWeight: 38 kDa and 20 kDa
Activity: Measuredby its binding ability in a functional ELISA. When biotinylated rmWnt-3a (0.5μg/mL, 100 μL/well) is captured on streptavidin-coated plate, rhGlypican-6binds with an apparent KD < 10 nM.
Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE: 38 kDaand 27-29 kDa, reducing conditions.
Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstituteat 100μg/mL in PBS.
Storage: Use a manual defrost freezer and avoid repeated freezethawcycles. 12months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °Cunder sterile conditions after reconstitution. 3 months, -20 to -70 °C understerile conditions after reconstitution.
Gene Name: GPC6 glypican 6 [ Homosapiens ]
Official Symbol: GPC6
Synonyms: GPC6; glypican 6;OMIMD1; glypican-6;glypican proteoglycan 6
Gene ID: 10082
mRNA Refseq: NM_005708
Protein Refseq: NP_005699
MIM: 604404
UniProt ID: Q9Y625
Chromosome Location: 13q32
Function: heparan sulfateproteoglycan binding

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