"Fcgr3" Related Products

Expand
Expand

Recombinant Mouse Fc Receptor, LgG, Low Affinity III, His-tagged

Cat. No.: Fcgr3-488M
Product Overview: Recombinant Mouse Fcgr3is expressed in Murine myeloma cell line, which has a molecule weight of 22.5kDa. Ala31 ­ Thr215, with a C­terminal 10­His tag.
Description: Receptors for the Fcregion of IgG (Fc γ Rs) are members of the Ig superfamily that function in theactivation or inhibition of immune responses such as degranulation, phagocytosis,ADCC (antibody­dependent cellular toxicity), cytokine release, and B cell proliferation.The Fc γ Rs have been divided into three classes based on close relationshipsin their extracellular domains; these groups are designated Fc γ RI (also knownas CD64),The coordinated functioning of activating and inhibitory receptors isnecessary for successful initiation, amplification, and termination of immuneresponses. Mouse CD16 is encoded by a single gene. The protein product is a typeI transmembrane protein having two extracellular Ig­like domains. It is expressedon a variety of myeloid and lymphoid cells and associates with Fc Rγ to deliveran activating signal upon ligand binding. Mouse CD32 is closely related to mouseCD16 throughout its extracellular domain (95% amino acid sequence identity), buthas a divergent cytoplasmic domain and functions as an inhibitory receptor. Togetherthese proteins constitute an activating/inhibiting receptor pair to regulate immuneresponses.
Source: Murine myeloma cell line,NS0­derived
Form: Supplied as a 0.2 μmfiltered solution in PBS.
N-terminal Sequence: Ala31
Molecular Weight: 22.5 kDa
Activity: Measured by its abilityto bind mouse IgG with an estimated KD < 15 nM.
Purity: >95%, by SDS­PAGEunder reducing conditions and visualized by silver stain.
Endotoxin Level: <1.0 EU per 1 μg ofthe protein by the LAL method.
Storage: Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
OfficialSymbol: Fcgr3
Gene Name: Fcgr3 Fc receptor, IgG, low affinityIII [ Mus musculus ]
Synonyms: Fcgr3; Fc receptor, IgG,low affinity III; CD16; fcRIII; low affinity immunoglobulin gamma Fc region receptorIII; FcgammaRIII; fc-gamma RIII; Fcg receptor III; igG Fc receptor III; Fc gammareceptor III
Gene ID: 14131
mRNA Refseq: NM_010188
Protein Refseq: NP_034318
Chromosome Location: 1 H3; 1 92.3 cM
Pathway: Adaptive Immune System;Immune System; Immunoregulatory interactions between a Lymphoid and a non-Lymphoidcell; Leishmaniasis; Natural killer cell mediated cytotoxicity; Osteoclast differentiation;Phagosome; Staphylococcus aureus infection; Systemic lupus erythematosus; Tuberculosis
Function: IgG binding; IgG receptoractivity; receptor activity

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information


Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.