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Active Recombinant Human Fc Receptor-Like 2, His-tagged

Cat.No. : FCRL2-497H
Product Overview : Recombinant Human FCRL2is expressed in Murine myeloma cell line, which has a molecule weight of 41.9kDa. Leu20 ­ Asp395, with a C­terminal 6­His tag.
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  • Gene Information
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Cat. No. : FCRL2-497H
Description : Fc receptor­like 2 (FCRL2),also known as FcRH2 and IRTA4, belongs to the family of glycoprotein homologsof classical immunoglobulin (Ig) Fc receptors. In human, the type I transmembraneFCRL protein family contains from three to nine immunoglobulin­like domains. Maturehuman FcRH2 consists of a 382 amino acid (aa) extracellular domain (ECD) withfour Ig­like C2­set domains, a 21 aa transmembrane segment, and an 86 aa cytoplasmicdomain with one ITAM­like, and two ITIM­like motifs. FCRL proteins are differentiallyexpressed among B cells. FCRL2 is preferentially expressed on naïve and CD27+memory B cells within the spleen, lymph nodes, tonsils, and peripheral blood.It is also expressed on most B cells in B cell chronic lymphocytic leukemia (B­CLL)patients. FCRL2 upregulation is associated with mutation of the immunoglobulinheavy chain variable (IGHV) and less aggressive forms of B­CLL.
Source : Mammalian cells
Form : Lyophilized from a 0.2μm filtered solution in PBS.
N-terminal Sequence : Leu20
Molecular Weight : 41.9 kDa
Activity : Measured by its abilityto bind human IgG with an estimated KD < 80 nM.
Purity : >95%, by SDS-PAGEunder reducing conditions and visualized by silver stain.
Endotoxin Level : <1.0 EU per 1 μg ofthe protein by the LAL method.
Reconstitution : Reconstitute at 100 μg/mLin sterile PBS.
Storage : Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
OfficialSymbol : FCRL2
Gene Name : FCRL2 Fc receptor-like 2 [ Homosapiens ]
Synonyms : FCRL2; Fc receptor-like2; FCRH2; IFGP4; IRTA4; SPAP1; CD307b; SPAP1A; SPAP1B; SPAP1C; CD307b antigen;Fc receptor-like protein 2; fcR-like protein 2; IFGP family protein 4; fc receptorhomolog 2; immunoglobulin superfamily Fc receptor, gp42; SH2 domain containingphosphatase anchor protein 1; SH2 domain-containing phosphatase anchor protein1; immune receptor translocation-associated protein 4; immunoglobulin receptortranslocation-associated protein 4; OTTHUMP00000020928; OTTHUMP00000020931
Gene ID : 79368
mRNA Refseq : NM_030764
Protein Refseq : NP_110391
MIM : 606509
UniProt ID : Q96LA5
Chromosome Location : 1q21
Function : SH3/SH2 adaptor activity;receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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