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Active Recombinant Mouse V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian)

Cat.No. : Erbb4-473M
Product Overview : Recombinant MouseErbb4 protein was expressed in Murine myeloma cell line, NS0-derived. Gln26 - Val657.
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  • Gene Information
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Cat. No. : Erbb4-473M
Description : Erbb4, alsocalled Her4 (human epidermal growth factor receptor 4) in humans, is a type Itransmembrane glycoprotein that is a member of the ErbB family of tyrosinekinase receptors named for a viral oncogene. ErbB family members serve asreceptors for the EGF family of growth factors. Mouse Erbb4 containsa 25 amino acid (aa) signal sequence, a 626 aa extracellular domain (ECD), a24 aa transmembrane region, and a 617 aa cytoplasmic domain.
Source : Mammalian cells
Form : Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence : Gln26 predicted
MolecularWeight : 97.5 kDa (monomer)
Activity : Measured by itsability to inhibit the biological activity of Neuregulin1ß1 on MCF7 humanbreast adenocarcinoma cells. Karey, K.P. et al. (1988) Cancer Research 48:4083.The ED50 for this effect is typically 3 12μg/mL in the presence of 10 ng/mLof rhNRG1 ß1.
Endotoxin Level : <1.0 EU per 1 μgof the protein by the LAL method.
Purity : >85%, by SDSPAGE underreducing conditions and visualized by silver stain.
Reconstitution : Reconstitute at 500μg/mL in sterile PBS.
Storage : Use a manual defrost freezer and avoid repeated freezethawcycles. 12 months from date of receipt, 20 to70°C as supplied. 1 month, 2 to 8 °C under sterile conditions afterreconstitution. 3 months, -20 to -70°C under sterile conditions afterreconstitution.
Gene Name : Erbb4 v-erb-a erythroblasticleukemia viral oncogene homolog 4 (avian) [ Mus musculus ]
Official Symbol : Erbb4
Synonyms : Erbb4; v-erb-aerythroblastic leukemia viral oncogene homolog 4 (avian); Her4;c-erbB-4; receptor tyrosine-protein kinase erbB-4; avian erythroblastosisoncogene B 4; proto-oncogene-like protein c-ErbB-4
Gene ID : 13869
mRNA Refseq : NM_010154
Protein Refseq : NP_034284
UniProt ID : O88459
Chromosome Location : 1 C3; 135.1 cM
Pathway : Calcium signalingpathway; Endocytosis; ErbB signaling pathway
Function : ATP binding;epidermal growth factor receptor binding; kinase activity; nucleotidebinding; protein binding; protein homodimerization activity; protein kinaseactivity; protein tyrosine kinase activity; receptor activity; receptorsignaling protein tyrosine kinase activity; transcription regulatory regionDNA binding; transferase activity; transferase activity, transferring phosphorus-containinggroups; transmembrane receptor protein tyrosine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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