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Recombinant Mouse V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian)

Cat. No.: Erbb4-473M
Product Overview: Recombinant MouseErbb4 protein was expressed in Murine myeloma cell line, NS0-derived. Gln26 - Val657.
Description: Erbb4, alsocalled Her4 (human epidermal growth factor receptor 4) in humans, is a type Itransmembrane glycoprotein that is a member of the ErbB family of tyrosinekinase receptors named for a viral oncogene. ErbB family members serve asreceptors for the EGF family of growth factors. Mouse Erbb4 containsa 25 amino acid (aa) signal sequence, a 626 aa extracellular domain (ECD), a24 aa transmembrane region, and a 617 aa cytoplasmic domain.
Source: Murine myeloma cellline, NS0-derived
Form: Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence: Gln26 predicted
MolecularWeight: 97.5 kDa (monomer)
Activity: Measured by itsability to inhibit the biological activity of Neuregulin1ß1 on MCF7 humanbreast adenocarcinoma cells. Karey, K.P. et al. (1988) Cancer Research 48:4083.The ED50 for this effect is typically 3 12μg/mL in the presence of 10 ng/mLof rhNRG1 ß1.
Endotoxin Level: <1.0 EU per 1 μgof the protein by the LAL method.
Purity: >85%, by SDSPAGE underreducing conditions and visualized by silver stain.
Reconstitution: Reconstitute at 500μg/mL in sterile PBS.
Storage: Use a manual defrost freezer and avoid repeated freezethawcycles. 12 months from date of receipt, 20 to70°C as supplied. 1 month, 2 to 8 °C under sterile conditions afterreconstitution. 3 months, -20 to -70°C under sterile conditions afterreconstitution.
Gene Name: Erbb4 v-erb-a erythroblasticleukemia viral oncogene homolog 4 (avian) [ Mus musculus ]
Official Symbol: Erbb4
Synonyms: Erbb4; v-erb-aerythroblastic leukemia viral oncogene homolog 4 (avian); Her4;c-erbB-4; receptor tyrosine-protein kinase erbB-4; avian erythroblastosisoncogene B 4; proto-oncogene-like protein c-ErbB-4
Gene ID: 13869
mRNA Refseq: NM_010154
Protein Refseq: NP_034284
UniProt ID: O88459
Chromosome Location: 1 C3; 135.1 cM
Pathway: Calcium signalingpathway; Endocytosis; ErbB signaling pathway
Function: ATP binding;epidermal growth factor receptor binding; kinase activity; nucleotidebinding; protein binding; protein homodimerization activity; protein kinaseactivity; protein tyrosine kinase activity; receptor activity; receptorsignaling protein tyrosine kinase activity; transcription regulatory regionDNA binding; transferase activity; transferase activity, transferring phosphorus-containinggroups; transmembrane receptor protein tyrosine kinase activity

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