Active Recombinant Mouse V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian)
Cat.No. : | Erbb4-473M |
Product Overview : | Recombinant MouseErbb4 protein was expressed in Murine myeloma cell line, NS0-derived. Gln26 - Val657. |
- Specification
- Gene Information
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Cat. No. : | Erbb4-473M |
Description : | Erbb4, alsocalled Her4 (human epidermal growth factor receptor 4) in humans, is a type Itransmembrane glycoprotein that is a member of the ErbB family of tyrosinekinase receptors named for a viral oncogene. ErbB family members serve asreceptors for the EGF family of growth factors. Mouse Erbb4 containsa 25 amino acid (aa) signal sequence, a 626 aa extracellular domain (ECD), a24 aa transmembrane region, and a 617 aa cytoplasmic domain. |
Source : | Mammalian cells |
Form : | Lyophilized from a0.2 μm filtered solution in PBS. |
N-terminalSequence : | Gln26 predicted |
MolecularWeight : | 97.5 kDa (monomer) |
Activity : | Measured by itsability to inhibit the biological activity of Neuregulin1ß1 on MCF7 humanbreast adenocarcinoma cells. Karey, K.P. et al. (1988) Cancer Research 48:4083.The ED50 for this effect is typically 3 12μg/mL in the presence of 10 ng/mLof rhNRG1 ß1. |
Endotoxin Level : | <1.0 EU per 1 μgof the protein by the LAL method. |
Purity : | >85%, by SDSPAGE underreducing conditions and visualized by silver stain. |
Reconstitution : | Reconstitute at 500μg/mL in sterile PBS. |
Storage : | Use a manual defrost freezer and avoid repeated freezethawcycles. 12 months from date of receipt, 20 to70°C as supplied. 1 month, 2 to 8 °C under sterile conditions afterreconstitution. 3 months, -20 to -70°C under sterile conditions afterreconstitution. |
Gene Name : | Erbb4 v-erb-a erythroblasticleukemia viral oncogene homolog 4 (avian) [ Mus musculus ] |
Official Symbol : | Erbb4 |
Synonyms : | Erbb4; v-erb-aerythroblastic leukemia viral oncogene homolog 4 (avian); Her4;c-erbB-4; receptor tyrosine-protein kinase erbB-4; avian erythroblastosisoncogene B 4; proto-oncogene-like protein c-ErbB-4 |
Gene ID : | 13869 |
mRNA Refseq : | NM_010154 |
Protein Refseq : | NP_034284 |
UniProt ID : | O88459 |
Chromosome Location : | 1 C3; 135.1 cM |
Pathway : | Calcium signalingpathway; Endocytosis; ErbB signaling pathway |
Function : | ATP binding;epidermal growth factor receptor binding; kinase activity; nucleotidebinding; protein binding; protein homodimerization activity; protein kinaseactivity; protein tyrosine kinase activity; receptor activity; receptorsignaling protein tyrosine kinase activity; transcription regulatory regionDNA binding; transferase activity; transferase activity, transferring phosphorus-containinggroups; transmembrane receptor protein tyrosine kinase activity |
Products Types
◆ Recombinant Protein | ||
ERBB4-2052H | Recombinant Human ERBB4 Protein, Fc/His-tagged | +Inquiry |
ERBB4-2116H | Recombinant Human ERBB4 Protein, MYC/DDK-tagged | +Inquiry |
ERBB4-1791R | Recombinant Rat ERBB4 Protein, His (Fc)-Avi-tagged | +Inquiry |
ERBB4-1325S | Recombinant Human ERBB4 Protein (R676-V1308), Tag Free | +Inquiry |
Erbb4-971M | Recombinant Mouse Erbb4 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
ERBB4-1543HCL | Recombinant Human ERBB4 cell lysate | +Inquiry |
ERBB4-895RCL | Recombinant Rat ERBB4 cell lysate | +Inquiry |
ERBB4-1417MCL | Recombinant Mouse ERBB4 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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