Recombinant Human FGFR1 Oncogene Partner, His-tagged

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Recombinant Human FGFR1 Oncogene Partner, His-tagged

FGFR1OP Related Products

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Cat. No. : FGFR1OP-6790H
Product Overview : Recombinant humanFGFR1OP protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography
Description : FGFR1OP, also knownas FGFR1 oncogene partner, belongs to the FGFR1OP family. This protein is alargely hydrophilic protein postulated to be a leucine-rich protein familymember. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and thefibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases ofmyeloproliferative disorder. The resulting chimeric protein contains theN-terminal leucine-rich region of this encoded protein fused to the catalyticdomain of FGFR1. This gene is thought to play an important role in normalproliferation and differentiation of the erythroid lineage
Form : Liquid. 20mMTris-HCl buffer (pH8.0) containing 10% glycerol, 1mM DTT
Molecular Weight : 43.5 kDa (403aa),confirmed by MALDI-TOF
Purity : > 85% by SDS -PAGE
Concentration : 1mg/ml (determinedby Bradford assay)
Sequences of aminoacids : MGSSHHHHHHSSGLVPRGSH MGSHMAATAA AVVAEEDTEL RDLLVQTLEN SGVLNRIKAE LRAAVFLALE EQEKVENKTPLVNESLKKFL NTKDGRLVAS LVAEFLQFFN LDFTLAVFQP ETSTLQGLEG RENLARDLGI IEAEGTVGGPLLLEVIRRCQ QKEKGPTTGE GALDLSDVHS PPKSPEGKTS AQTTPSKKAN DEANQSDTSV SLSEPKSKSSLHLLSHETKI GSFLSNRTLD GKDKAGLCPD EDDMEGDSFF DDPIPKPEKT YGLRKEPRKQ AGSLASLSDAPPLKSGLSSL AGAPSLKDSE SKRGNTVLKD LKLISDKIGS LGLGTGEDDD YVDDFNSTSH RSEKSEISIGEEIEEDLSVE IDDINTSDKL DDLTQDLTVS QLSDVADYLE DVA
Storage : Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles
PDB rendering based on 2d68. :

Gene Name : FGFR1OP FGFR1 oncogene partner[Homo sapiens]
Official Symbol : FGFR1OP
Synonyms : FGFR1OP; FGFR1 oncogene partner;FOP; OTTHUMP00000017612; OTTHUMP00000017613; fibroblast growth factorreceptor 1 oncogene partner
Gene ID : 11116
mRNA Refseq : NM_194429
Protein Refseq : NP_919410
MIM : 605392
UniProt ID : O95684
Chromosome Location : 6q27
Function : protein binding; proteinhomodimerization activity; protein kinase binding; protein tyrosine kinaseinhibitor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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