Mouse Anti-Human NANS Monoclonal Antibody

• Cat.No.: CAB-11470MH
• Product Overview: Anti-human NANS mAb,is derived from hybridization of mouse F0 myeloma cells with spleen cellsfrom BALB/c mice immunized with a recombinant human NANS protein.

Specification

• Cat. No.: CAB-11470MH
• Antigen Description: NANS (Sialic acidssynthease) is an enzyme that functions in the biosynthetic pathways of sialicacids. Expressed ubiquitously, NANS enzymatically catalyzes the H2O-dependentformation of N-acetylneuraminic acid (Neu5Ac) and2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), both of which aresialic acids. NANS uses N-acetylmannosamine 6-phosphate as a substrate forNeu5Ac synthesis and mannose 6-phosphate as a substrate for KDN synthesis.
• Immunogen: Recombinant human NANS(1-359aa) purified from E. coli.
• Host: Mouse
• Isotype: MouseIgG1 heavy chain and κ light chain.
• Application: ELISA; WB
• Clone: BU2H7
• Description: NANS isan enzyme that in humans is encoded by the NANS gene.
• Concentration: 1 mg/ml
• Form: Liquid.In Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
• Usage: The antibodyhas been tested by ELISA, Western blot analysis to assure specificity andreactivity. Since application varies, however, each investigation should betitrated by the reagent to obtain optimal results. Recommended dilution rangefor Western blot analysis is 1:1000.
• Storage: Can bestored at +4°C. For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: NANS N-acetylneuraminicacid synthase [ Homo sapiens ]
• Official Symbol: NANS
• Synonyms: NANS; N-acetylneuraminic acid synthase; SAS; sialic acidsynthase; N-acetylneuraminate synthase; sialic acid phosphate synthase;N-acetylneuraminate-9-phosphate synthase; N-acetylneuraminic acid phosphatesynthase; EC 2.5.1.56; EC 2.5.1.57; OTTHUMP00000021769
• Gene ID: 54187
• mRNA Refseq: NM_018946
• Protein Refseq: NP_061819
• MIM: 605202
• UniProt ID: Q9NR45
• Chromosome Location: 9p24.1-p23
• Pathway: Amino sugar and nucleotide sugarmetabolism; CMP-N-acetylneuraminate biosynthesis I (eukaryotes); Metabolicpathways; superpathway of sialic acid and CMP-sialic acid biosynthesis
• Function: N-acetylneuraminate synthaseactivity; N-acylneuraminate cytidylyltransferase activity;N-acylneuraminate-9-phosphate synthase activity; transferase activity