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Recombinant Human Aldehyde Dehydrogenase 1 Family, Member L1, His-tagged

Cat.No. : ALDH1L1-491H
Product Overview : Recombinant Human ALDH1L1protein was expressed as 6-his-tagged fusion protein by E. coli and purifiedby Ni-sepharose. The purified protein was resolved in 1M PBS (58mMNa2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.) added with 300mM Imidazole and 0.7% Sarcosyl,15%glycerol. MW= 44 kDa.
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Cat. No. : ALDH1L1-491H
Description : ALDH1L1 encoded bythis gene catalyzes the conversion of 10-formyltetrahydrofolate, NADP, andwater to tetrahydrofolate, NADPH, and carbon dioxide. ALDH1L1 belongs to thealdehyde dehydrogenase family and is responsible for formate oxidation invivo. Deficiencies in ALDH1L1 can result in an accumulation of formate andsubsequent methanol poisoning.
Host : E. coli
Antigen peptideregion : 157-505aa
Molecular Weight : 44 kDa
Full length : False
Storage : Theprotein is stored in PBS buffer at -20°C.Repeated freeze-thaw cycles should be avoided.
Gene Name : ALDH1L1 aldehyde dehydrogenase1 family, member L1 [ Homo sapiens ]
Official Symbol : ALDH1L1
Synonyms : ALDH1L1;aldehyde dehydrogenase 1 family, member L1; FDH; FTHFD; 10-fTHF; cytosolic10-formyltetrahydrofolate dehydrogenase; 10-FTHFDH; formyltetrahydrofolatedehydrogenase; 10-formyltetrahydrofolate dehydrogenase; aldehydedehydrogenase family 1 member L1; EC 1.5.1.6; DKFZp781N0997;OTTHUMP00000155221; OTTHUMP00000214696; OTTHUMP00000214700;OTTHUMP00000222724
Gene ID : 10840
mRNA Refseq : NM_012190
Protein Refseq : NP_036322
MIM : 600249
UniProt ID : O75891
Chromosome Location : 3q21.3
Pathway : One CarbonMetabolism; One carbon pool by folate
Function : acyl carrieractivity; catalytic activity; cofactor binding; formyltetrahydrofolatedehydrogenase activity; hydroxymethyl-, formyl- and related transferaseactivity; methyltransferase activity; oxidoreductase activity; oxidoreductaseactivity, acting on the aldehyde or oxo group of donors, NAD or NADP asacceptor

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the current challenges in targeting ALDH1L1 protein for therapeutic purposes? 10/14/2022

The precise role of ALDH1L1 protein in various diseases is still being elucidated, and developing effective therapies targeting this protein presents challenges.

What are the potential side effects of targeting ALDH1L1 protein for therapeutic purposes? 04/04/2022

Targeting ALDH1L1 protein may have potential side effects related to its role in folate metabolism and neural stem cell maintenance.

How does the expression of ALDH1L1 protein vary in different cancer types? 07/07/2021

The expression of ALDH1L1 protein can vary significantly across different cancer types, potentially making it a valuable target for personalized therapies.

Can ALDH1L1 protein be a potential therapeutic target for cancer treatment? 03/02/2020

Research suggests that targeting ALDH1L1 protein could potentially be a strategy for cancer treatment, but further studies are needed to determine its efficacy.

How does the expression of ALDH1L1 protein change with age? 06/13/2018

Research suggests that the expression of ALDH1L1 protein may decrease with age, which could have implications for age-related diseases.

Customer Reviews (3)

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Reviews
08/17/2022

    One notable advantage of using the ALDH1L1 protein is the outstanding technical support provided by its manufacturer.

    04/22/2021

      The knowledgeable and responsive support team offers valuable assistance and expertise, making troubleshooting and problem-solving much more efficient.

      10/07/2017

        Its purity and functionality have been extensively tested, ensuring reliable and reproducible results in my research.

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