"HDAC6" Related Products

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Recombinant Human Histone Deacetylase 6, FLAG-tagged

Cat. No.: HDAC6-398H
Product Overview: Recombinanthuman HDAC6 was expressed in E. coli as the full length protein with anN-terminal FLAG tag. The molecular weight of the protein is 132 kDa.
Description: HDAC6is a histone deacetylase containig two HDAC catalytic domains. HDAC6 is anenzyme that in humans is encoded by the HDAC6 gene. Histones play a critical rolein transcriptional regulation, cell cycle progression, and developmentalevents. It contains an internal duplication of two catalytic domains whichappear to function independently of each other.
Source: E. coli
Species: Human
Reconstitution: 20 mM Tris-HCl (pH7.3), 300 mM KCl, 0.2 mM EDTA and 20%glycerol.
Contents: 10g recombinant HDAC6 protein, 0.5 g/l.
Dilution of Protein: RecombinantHDAC6 is supplied in solution and should be kept as a solution in ordertomaintain full activity.
Application: RecombinantHDAC6 is suitable for use in histone deacetylase assays. Arecommendedstarting point for the HDAC assay is 20-100 ng of recombinant proteinperreaction.
Storage: Recombinantproteins in solution are temperature sensitive and should be stored at-80°Cto prevent degradation. Avoid repeated freeze/thaw cycles and keep on icewhennot in storage.
Gene Name: HDAC6 histonedeacetylase 6 [ Homo sapiens ]
Official Symbol: HDAC6
Synonyms: HDAC6;histone deacetylase 6; HD6; JM21; FLJ16239; EC 3.5.1.98; KIAA0901;OTTHUMP00000032398; OTTHUMP00000197663
Gene ID: 10013
mRNA Refseq: NM_006044
Protein Refseq: NP_006035
MIM: 300272
UniProt ID: Q9UBN7
Chromosome Location: Xp11.23
Pathway: Cell cycle; NOTCH1 Intracellular DomainRegulates Transcription; Signal Transduction; Signaling by NOTCH; Signalingby NOTCH1; Signaling events mediated by HDAC Class I; Signaling eventsmediated by HDAC Class II; TNF-alpha/NF-kB Signaling Pathway
Function: Hsp90 protein binding; NAD-dependenthistone deacetylase activity (H3-K14 specific); NAD-dependent histonedeacetylase activity (H3-K9 specific); NAD-dependent histone deacetylaseactivity (H4-K16 specific); actin binding; alpha-tubulin binding;beta-catenin binding; beta-tubulin binding; dynein complex binding; enzymebinding; histone deacetylase activity; histone deacetylase activity (H3-K16specific); histone deacetylase binding; hydrolase activity; metal ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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