"HDAC6" Related Products

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Recombinant Human Histone Deacetylase 6, FLAG-tagged

Cat. No. : HDAC6-398H
Product Overview : Recombinanthuman HDAC6 was expressed in E. coli as the full length protein with anN-terminal FLAG tag. The molecular weight of the protein is 132 kDa.
Description : HDAC6is a histone deacetylase containig two HDAC catalytic domains. HDAC6 is anenzyme that in humans is encoded by the HDAC6 gene. Histones play a critical rolein transcriptional regulation, cell cycle progression, and developmentalevents. It contains an internal duplication of two catalytic domains whichappear to function independently of each other.
Source : E. coli
Species : Human
Reconstitution : 20 mM Tris-HCl (pH7.3), 300 mM KCl, 0.2 mM EDTA and 20%glycerol.
Contents : 10g recombinant HDAC6 protein, 0.5 g/l.
Dilution of Protein : RecombinantHDAC6 is supplied in solution and should be kept as a solution in ordertomaintain full activity.
Application : RecombinantHDAC6 is suitable for use in histone deacetylase assays. Arecommendedstarting point for the HDAC assay is 20-100 ng of recombinant proteinperreaction.
Storage : Recombinantproteins in solution are temperature sensitive and should be stored at-80°Cto prevent degradation. Avoid repeated freeze/thaw cycles and keep on icewhennot in storage.
Gene Name : HDAC6 histonedeacetylase 6 [ Homo sapiens ]
Official Symbol : HDAC6
Synonyms : HDAC6;histone deacetylase 6; HD6; JM21; FLJ16239; EC 3.5.1.98; KIAA0901;OTTHUMP00000032398; OTTHUMP00000197663
Gene ID : 10013
mRNA Refseq : NM_006044
Protein Refseq : NP_006035
MIM : 300272
UniProt ID : Q9UBN7
Chromosome Location : Xp11.23
Pathway : Cell cycle; NOTCH1 Intracellular DomainRegulates Transcription; Signal Transduction; Signaling by NOTCH; Signalingby NOTCH1; Signaling events mediated by HDAC Class I; Signaling eventsmediated by HDAC Class II; TNF-alpha/NF-kB Signaling Pathway
Function : Hsp90 protein binding; NAD-dependenthistone deacetylase activity (H3-K14 specific); NAD-dependent histonedeacetylase activity (H3-K9 specific); NAD-dependent histone deacetylaseactivity (H4-K16 specific); actin binding; alpha-tubulin binding;beta-catenin binding; beta-tubulin binding; dynein complex binding; enzymebinding; histone deacetylase activity; histone deacetylase activity (H3-K16specific); histone deacetylase binding; hydrolase activity; metal ion binding

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