"HDAC6" Related Products

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Recombinant Human Histone Deacetylase 6, FLAG-tagged

Cat. No. : HDAC6-400H
Product Overview : HumanHDAC6 full length with C-terminal Flag tag, MW: 132 kDa, expressed inbaculovirus expression system. Protein was purified by affinitychromatography and gel filtration.
Description : HDAC6is a histone deacetylase containig two HDAC catalytic domains. HDAC6 is anenzyme that in humans is encoded by the HDAC6 gene. Histones play a criticalrole in transcriptional regulation, cell cycle progression, and developmentalevents. It contains an internal duplication of two catalytic domains whichappear to function independently of each other.
Source : Baculovirus
Species : Human
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/ulFlag peptide,and 20% Glycerol.
Purity : ≥ 33%
Molecular Weight : 132 kDa
Specific Activity : 146pmol/min/µg. Assay condition: 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mMKCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 30 µM BPS HDAC substrate, and HDAC6.Incubation condition: 30 min at 37°C.
Application : Useful forthe study of enzyme kinetics, screening inhibitors, and selectivityprofiling.
Storage : >6 months at -80°C.
Gene Name : HDAC6 histonedeacetylase 6 [ Homo sapiens ]
Official Symbol : HDAC6
Synonyms : HDAC6;histone deacetylase 6; HD6; JM21; FLJ16239; EC 3.5.1.98; KIAA0901;OTTHUMP00000032398; OTTHUMP00000197663
Gene ID : 10013
mRNA Refseq : NM_006044
Protein Refseq : NP_006035
MIM : 300272
UniProt ID : Q9UBN7
Chromosome Location : Xp11.23
Pathway : Cell cycle; NOTCH1 Intracellular DomainRegulates Transcription; Signal Transduction; Signaling by NOTCH; Signalingby NOTCH1; Signaling events mediated by HDAC Class I; Signaling eventsmediated by HDAC Class II; TNF-alpha/NF-kB Signaling Pathway
Function : Hsp90 protein binding; NAD-dependenthistone deacetylase activity (H3-K14 specific); NAD-dependent histonedeacetylase activity (H3-K9 specific); NAD-dependent histone deacetylaseactivity (H4-K16 specific); actin binding; alpha-tubulin binding; beta-cateninbinding; beta-tubulin binding; dynein complex binding; enzyme binding;histone deacetylase activity; histone deacetylase activity (H3-K16 specific);histone deacetylase binding; hydrolase activity; metal ion binding

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