"HDAC6" Related Products

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Recombinant Human Histone Deacetylase 6, FLAG-tagged

Cat. No.: HDAC6-400H
Product Overview: HumanHDAC6 full length with C-terminal Flag tag, MW: 132 kDa, expressed inbaculovirus expression system. Protein was purified by affinitychromatography and gel filtration.
Description: HDAC6is a histone deacetylase containig two HDAC catalytic domains. HDAC6 is anenzyme that in humans is encoded by the HDAC6 gene. Histones play a criticalrole in transcriptional regulation, cell cycle progression, and developmentalevents. It contains an internal duplication of two catalytic domains whichappear to function independently of each other.
Source: Baculovirus
Species: Human
Form: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/ulFlag peptide,and 20% Glycerol.
Purity: ≥ 33%
Molecular Weight: 132 kDa
Specific Activity: 146pmol/min/µg. Assay condition: 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mMKCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 30 µM BPS HDAC substrate, and HDAC6.Incubation condition: 30 min at 37°C.
Application: Useful forthe study of enzyme kinetics, screening inhibitors, and selectivityprofiling.
Storage: >6 months at -80°C.
Gene Name: HDAC6 histonedeacetylase 6 [ Homo sapiens ]
Official Symbol: HDAC6
Synonyms: HDAC6;histone deacetylase 6; HD6; JM21; FLJ16239; EC 3.5.1.98; KIAA0901;OTTHUMP00000032398; OTTHUMP00000197663
Gene ID: 10013
mRNA Refseq: NM_006044
Protein Refseq: NP_006035
MIM: 300272
UniProt ID: Q9UBN7
Chromosome Location: Xp11.23
Pathway: Cell cycle; NOTCH1 Intracellular DomainRegulates Transcription; Signal Transduction; Signaling by NOTCH; Signalingby NOTCH1; Signaling events mediated by HDAC Class I; Signaling eventsmediated by HDAC Class II; TNF-alpha/NF-kB Signaling Pathway
Function: Hsp90 protein binding; NAD-dependenthistone deacetylase activity (H3-K14 specific); NAD-dependent histonedeacetylase activity (H3-K9 specific); NAD-dependent histone deacetylaseactivity (H4-K16 specific); actin binding; alpha-tubulin binding; beta-cateninbinding; beta-tubulin binding; dynein complex binding; enzyme binding;histone deacetylase activity; histone deacetylase activity (H3-K16 specific);histone deacetylase binding; hydrolase activity; metal ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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