Active Recombinant Human MMP14

• Cat.No.: MMP14-162H
• Product Overview: Recombinant human MMP14 was produced in mammalian cells, 59 kDa.

Specification

• Cat. No.: MMP14-162H
• Description: Proteinsof the matrix metalloproteinase (MMP) family are involved in the breakdown ofextracellular matrix in normal physiological processes, such as embryonicdevelopment, reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's are secreted asinactive proproteins which are activated when cleaved by extracellularproteinases. However, the protein encoded by this gene is a member of themembrane-type MMP (MT-MMP) subfamily; each member of this subfamily containsa potential transmembrane domain suggesting that these proteins are expressedat the cell surface rather than secreted. This protein activates MMP2protein, and this activity may be involved in tumor invasion.
• Source: Mammalian cells
• Species: Human
• Concentration: 10 µg/25 µl
• Purity: >95%
• Activity: Pro-form activated by incubation with Furin.
• Endotoxin: < 1.0 EU per µg of the protein as determined by the LALmethod.
• Formulation: Liquid. In 50 mM HEPES, pH 7.5, containing 400 mMsodium chloride, 5 mM calcium chloride, 20 µlM zinc chloride and 20%glycerol.
• Stability: Stable at least 6 months when stored at -20°C.
• Storage: Shortterm, −20°C; Long term −80°C. Avoid freeze/thaw cycles.
• OfficialSymbol: MMP14

Gene Information

• Gene Name: MMP14 matrix metallopeptidase 14(membrane-inserted) [ Homo sapiens ]
• Synonyms: MMP14; matrix metallopeptidase14 (membrane-inserted); 1; MMP-X1; MT-MMP; MT1MMP; MTMMP1; MT1-MMP; MT-MMP 1;matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane-typematrix metalloproteinase 1; membrane-type-1 matrix metalloproteinase; MMP-14;EC 3.4.24.80; OTTHUMP00000027917; EC 3.4.24
• Gene ID: 4323
• mRNA Refseq: NM_004995
• Protein Refseq: NP_004986
• MIM: 600754
• UniProt ID: P50281
• Chromosome Location: 14q11-q12
• Pathway: Activation of Matrix Metalloproteinases; Extracellularmatrix organization; GnRH signaling pathway
• Function: calcium ion binding; integrin binding; metalloendopeptidaseactivity