Rabbit Monoclonal Antibody to Human Nephroblastoma Overexpressed


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Rabbit Monoclonal Antibody to Human Nephroblastoma Overexpressed

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Cat.No. : CAB11588RH
Product Overview : Rabbit Monoclonal Antibody to Human Nephroblastoma Overexpressed
Antigen Description : Protein NOV homolog, also known as Nephroblastoma-overexpressed gene protein homolog, NOV, and CCN3, is secreted protein which belongs to the?CCN family. CCN3 expression was observed in a broad variety of tissues from the early stage of development. It contains one?CTCK (C-terminal cystine knot-like) domain, one?IGFBP N-terminal domain, one?TSP type-1 domain, and one?VWFC domain. CCN3, a founding member of the CCN family of growth regulators, was linked with hematology in 2003 when it was detected in human serum. CCN3 acts through the core stem cell signalling pathways including Notch and Bone Morphogenic Protein, connecting CCN3 with the modulation of self-renewal and maturation of a number of cell lineages including hematopoietic, osteogenic and chondrogenic. Altered CCN3 expression is associated with numerous solid tumors including glioblastoma, melanoma, adrenocortical tumours, prostate cancer and bone malignancies including osteosarcoma. CCN3 may affect the extracellular environment of the niche for hematopoietic stem cells. CCN3 has emerged as a key player in stem cell regulation, hematopoiesis and a crucial component within the bone marrow microenvironment.
Specificity : Human CCN3 / NOV / IGFBP9. No cross-reactivity in ELISA with Human WISP1; Human cell lysate (293 cell line)
Immunogen : Recombinant Human CCN3 / NOV / IGFBP9 Protein
Host : Rabbit
Isotype : Rabbit IgG
Species : Human
Clone : A131
Applications : Western blot; ELISA
Dilution : Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human NOV in WB.Direct ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human NOV. The detection limit for Human NOV is approximately 0.00975 ng/well.
Preparation : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Human CCN3 / NOV / IGFBP9
Format : 0.2 μm filtered solution in PBS with 5% trehalose
Storage : This antibody can be stored at 2-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name : NOV nephroblastoma overexpressed [ Homo sapiens ]
Official Symbol : NOV
Synonyms : NOV; nephroblastoma overexpressed; nephroblastoma overexpressed gene; protein NOV homolog; CCN3; IGFBP9; CCN family member 3; IGF-binding protein 9; insulin-like growth factor-binding protein 9; nephroblastoma-overexpressed gene protein homolog; NOVh; IBP-9; IGFBP-9;
Gene ID : 4856
mRNA Refseq : NM_002514
Protein Refseq : NP_002505
MIM : 164958
UniProt ID : P48745
Chromosome Location : 8q24.12
Pathway : Delta-Notch Signaling Pathway, organism-specific biosystem;
Function : growth factor activity; insulin-like growth factor binding;

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