"IDUA" Related Products


Recombinant Human IDUA, His-tagged

Cat. No.: IDUA-27H
Product Overview: Recombinant human IDUA (Ala26­Pro653), fused with 10*his tag at C-terminal, was expressed in Mouse NSO Cells, 71 kDa .
Description: α-L-Iduronidase encoded by the IDUA gene is an important enzyme required for the lysosomal degradation of glycosaminoglycans (GAGs). It hydrolyzes the non-reducing terminal α-L-iduronic acid residues in GAGs including dermatan sulfate and heparan sulfate. Mutations in IDUA that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). MPS I causes progressive cellular, tissue and organ damage, and several clinical studies using enzyme replacement therapy have shown promising benefit.
Source: Mouse NSO Cells
Species: Human
Form: Supplied as a 0.2 μm filtered solution in Sodium Acetate and NaCl.
Purity: > 95% as determined by SDS-PAGE
Activity: Measured by its ability to cleave a fluorogenic substrate, 4­Methylumbelliferyl α­L­iduronide. The specific activity is >7,500 pmol/min/µg.
EndotoxinLevel: <1.0 EU per 1 μg of the protein by the LAL method
Storage: 6 months from date of receipt, ­20 to ­70 °C as supplied; 3 months, ­20 to ­70 °C under sterile conditions after opening.
OfficialSymbol: IDUA
Gene Name: IDUA iduronidase, alpha-L- [ Homo sapiens ]
Synonyms: IDUA;iduronidase, alpha-L-; IDA; MPS1; Alpha-L-iduronidase; EC; OTTHUMP000002173092; OTTHUMP00000112666; α-L-iduronidase precursor
Gene ID: 3425
mRNA Refseq: NM_000203
Protein Refseq: NP_000194
MIM: 252800
UniProt ID: P35475
Chromosome Location: 4p16.3
Pathway: Dermatan sulfatedegradation; Dermatan sulfate degradation; Glycosaminoglycan degradation; Glycosaminoglycan degradation; Heparan sulfate degradation; Heparan sulfatedegradation; Lysosome; Metabolic pathways
Function: L-iduronidaseactivity; cation binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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