"IDUA" Related Products

Expand
Expand

Recombinant Human IDUA, His-tagged

Cat. No.: IDUA-27H
Product Overview: Recombinant human IDUA (Ala26­Pro653), fused with 10*his tag at C-terminal, was expressed in Mouse NSO Cells, 71 kDa .
Description: α-L-Iduronidase encoded by the IDUA gene is an important enzyme required for the lysosomal degradation of glycosaminoglycans (GAGs). It hydrolyzes the non-reducing terminal α-L-iduronic acid residues in GAGs including dermatan sulfate and heparan sulfate. Mutations in IDUA that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). MPS I causes progressive cellular, tissue and organ damage, and several clinical studies using enzyme replacement therapy have shown promising benefit.
Source: Mouse NSO Cells
Species: Human
Form: Supplied as a 0.2 μm filtered solution in Sodium Acetate and NaCl.
Purity: > 95% as determined by SDS-PAGE
Activity: Measured by its ability to cleave a fluorogenic substrate, 4­Methylumbelliferyl α­L­iduronide. The specific activity is >7,500 pmol/min/µg.
EndotoxinLevel: <1.0 EU per 1 μg of the protein by the LAL method
Storage: 6 months from date of receipt, ­20 to ­70 °C as supplied; 3 months, ­20 to ­70 °C under sterile conditions after opening.
OfficialSymbol: IDUA
Gene Name: IDUA iduronidase, alpha-L- [ Homo sapiens ]
Synonyms: IDUA;iduronidase, alpha-L-; IDA; MPS1; Alpha-L-iduronidase; EC 3.2.1.76; OTTHUMP000002173092; OTTHUMP00000112666; α-L-iduronidase precursor
Gene ID: 3425
mRNA Refseq: NM_000203
Protein Refseq: NP_000194
MIM: 252800
UniProt ID: P35475
Chromosome Location: 4p16.3
Pathway: Dermatan sulfatedegradation; Dermatan sulfate degradation; Glycosaminoglycan degradation; Glycosaminoglycan degradation; Heparan sulfate degradation; Heparan sulfatedegradation; Lysosome; Metabolic pathways
Function: L-iduronidaseactivity; cation binding

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information


Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.