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Recombinant Human Lin-28 Homolog B (C. elegans), His-tagged

Cat.No. : LIN28B-7186H
Product Overview : Recombinant human Lin28B protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 29.5 kDa.
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Description : Lin28B belongs to the lin-28 family. LIN28 protein is a microRNA-binding protein that binds to and enhances the translation of the IGF-2 (insulin-like growth factor 2) mRNA. Lin28B is acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 10% glycerol,2mM DTT.
Molecular Mass : 29.5 kDa (273aa) confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)
Protein length : 1-250aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSMAEGGAS KGGGEEPGKL PEPAEEESQV LRGTGHCKWF NVRMGFGFIS MINREGSPLD IPVDVFVHQS KLFMEGFRSL KEGEPVEFTF KKSSKGLESI RVTGPGGSPC LGSERRPKGK TLQKRKPKGD RCYNCGGLDH HAKECSLPPQ PKKCHYCQSI MHMVANCPHK NVAQPPASSQ GRQEAESQPC TSTLPREVGG GHGCTSPPFP QEARAEISER SGRSPQEASS TKSSIAPEEQ SKKGPSVQKR KKT
Purity : >85% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 0.25 mg/ml (determined by Bradford assay)
Gene Name : LIN28B lin-28 homolog B (C. elegans) [ Homo sapiens ]
Official Symbol : LIN28B
Synonyms : LIN28B; lin-28 homolog B (C. elegans); protein lin-28 homolog B; CSDD2; FLJ16517; lin-28B; Lin-28.2;
Gene ID : 389421
mRNA Refseq : NM_001004317
Protein Refseq : NP_001004317
MIM : 611044
UniProt ID : Q6ZN17
Chromosome Location : 6q21
Pathway : Validated targets of C-MYC transcriptional activation, organism-specific biosystem;
Function : DNA binding; RNA binding; metal ion binding; protein binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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