Recombinant Human TSC22 Domain Family, Member 3, His-tagged

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Recombinant Human TSC22 Domain Family, Member 3, His-tagged

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Cat.No. : TSC22D3-7192H
Product Overview : Recombinant human TSC22D3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 17.2 kDa.
Description : TSC22 domain family protein 3, also known as TSC22D3, protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, TSC22D3 plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, TSC22D3 inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT.
Molecular Mass : 17.2 kDa (157aa) confirmed by MALDI-TOF
Protein length : 1-134aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSMNTEMYQ TPMEVAVYQL HNFSISFFSS LLGGDVVSVK LDNSASGASV VAIDNKIEQA MDLVKNHLMY AVREEVEILK EQIRELVEKN SQLERENTLL KTLASPEQLE KFQSCLSPEE PAPESPQVPE APGGSAV
Purity : >85% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name : TSC22D3 TSC22 domain family, member 3 [ Homo sapiens ]
Official Symbol : TSC22D3
Synonyms : TSC22D3; TSC22 domain family, member 3; delta sleep inducing peptide, immunoreactor , DSIPI; TSC22 domain family protein 3; DIP; GILZ; glucocorticoid induced leucine zipper; hDIP; TSC 22R; TSC-22-like protein; TSC-22 related protein; TSC-22-related protein; DSIP-immunoreactive peptide; DSIP-immunoreactive leucine zipper protein; delta sleep-inducing peptide immunoreactor; delta sleep inducing peptide, immunoreactor; glucocorticoid-induced leucine zipper protein; DSIPI; TSC-22R; DKFZp313A1123;
Gene ID : 1831
mRNA Refseq : NM_001015881
Protein Refseq : NP_001015881
MIM : 300506
UniProt ID : Q99576
Chromosome Location : Xq22.3
Function : sequence-specific DNA binding transcription factor activity;

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