"IRAK2" Related Products

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Recombinant Human IRAK2 (Active), GST-tagged

Cat.No. : IRAK2-1417H
Product Overview : Recombinant full-length human IRAK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : Interleukin-1 receptor-associated kinase 2 (IRAK2) is important downstream signaling components of Toll-like receptors (TLRs). IRAKs were first described as signal transducers for IL-1 and later have been implicated in signal transduction of other members of the Toll/IL-1 receptor family. The interleukin-1 receptor (IL-1R) signaling pathway leads to NF?B activation in mammals. To date, four mammalian IRAKs have been identified (IRAK-1, IRAK-2, IRAK-4, and IRAK-M). It is believed that IRAK-2 could be an additional therapeutic target for inhibiting IL-1-induced inflammation.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 6 nmol/min/mg
Molecular Mass : ~103 kDa
Protein length : Full length
Purity : >75%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : IRAK2 interleukin-1 receptor-associated kinase 2 [ Homo sapiens ]
Official Symbol : IRAK2
Synonyms : IRAK2; interleukin-1 receptor-associated kinase 2; interleukin-1 receptor-associated kinase-like 2; interleukin-1 receptor associated kinase-2; IRAK-2; MGC150550;
Gene ID : 3656
mRNA Refseq : NM_001570
Protein Refseq : NP_001561
MIM : 603304
UniProt ID : O43187
Chromosome Location : 3p25.2
Pathway : Activated TLR4 signalling, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; IL-1 Signaling Pathway, organism-specific biosystem; IRAK2 mediated activation of TAK1 complex, organism-specific biosystem; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, organism-specific biosystem;
Function : ATP binding; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; transferase activity, transferring phosphorus-containing groups;

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