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Recombinant Human MUSK (Active), GST-tagged

Cat.No.: MUSK-1434H
Product Overview: Recombinant human MUSK (519-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: MUSK is a receptor tyrosine kinase necessary for neuromuscular junction formation. MUSK gene expression is highly regulated during neuromuscular junction and it is involved in intercellular communication present on the surface of cells that are activated by specific protein ligands. MUSK members play a key role in growth and differentiation of those cell types. Agrin signals through MUSK to cluster acetylcholine receptors on the postsynaptic membrane of the neuromuscular junction. DOK7, a MUSK-interacting cytoplasmic protein, is essential for MUSK activation in cultured myotubes. MUSK also plays a critical role in the development of normal blood vessels.
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity: 6.7 nmol/min/mg
Molecular Mass: ~63 kDa
Protein length: 519 aa-end
Purity: >85%
Applications: Kinase Assay, Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: MUSK muscle, skeletal, receptor tyrosine kinase [ Homo sapiens ]
Official Symbol: MUSK
Synonyms: MUSK; muscle, skeletal, receptor tyrosine kinase; muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; MGC126323; MGC126324;
Gene ID: 4593
mRNA Refseq: NM_001166280
Protein Refseq: NP_001159752
MIM: 601296
UniProt ID: O15146
Chromosome Location: 9q31.3-q32
Function: ATP binding; PDZ domain binding; nucleotide binding; protein tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity;

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