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Active Recombinant Human MUSK, GST-tagged

Cat.No. : MUSK-1434H
Product Overview : Recombinant human MUSK (519-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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  • Gene Information
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Description : MUSK is a receptor tyrosine kinase necessary for neuromuscular junction formation. MUSK gene expression is highly regulated during neuromuscular junction and it is involved in intercellular communication present on the surface of cells that are activated by specific protein ligands. MUSK members play a key role in growth and differentiation of those cell types. Agrin signals through MUSK to cluster acetylcholine receptors on the postsynaptic membrane of the neuromuscular junction. DOK7, a MUSK-interacting cytoplasmic protein, is essential for MUSK activation in cultured myotubes. MUSK also plays a critical role in the development of normal blood vessels.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity : 6.7 nmol/min/mg
Molecular Mass : ~63 kDa
Protein length : 519 aa-end
Purity : >85%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : MUSK muscle, skeletal, receptor tyrosine kinase [ Homo sapiens ]
Official Symbol : MUSK
Synonyms : MUSK; muscle, skeletal, receptor tyrosine kinase; muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; MGC126323; MGC126324;
Gene ID : 4593
mRNA Refseq : NM_001166280
Protein Refseq : NP_001159752
MIM : 601296
UniProt ID : O15146
Chromosome Location : 9q31.3-q32
Function : ATP binding; PDZ domain binding; nucleotide binding; protein tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is MUSK protein targeted in the treatment of autoimmune myasthenia gravis? 02/19/2019

In autoimmune myasthenia gravis, immunosuppressive therapies and acetylcholinesterase inhibitors are commonly used to manage symptoms, and some treatments specifically target the immune response against MUSK.

Can MUSK protein abnormalities be detected early in life? 02/27/2018

Yes, genetic testing and other diagnostic measures can identify MUSK protein abnormalities early in life, enabling prompt intervention and management.

Are there diagnostic tests for MUSK-related disorders? 07/10/2017

Yes, diagnostic tests such as genetic testing and antibody assays can be employed to identify MUSK-related disorders.

How does MUSK protein contribute to muscle regeneration? 01/31/2017

MUSK protein plays a role in signaling pathways that contribute to muscle regeneration, making it an important factor in tissue repair.

Can MUSK protein be a target for gene therapy? 08/19/2016

Yes, gene therapy approaches aimed at restoring normal MUSK function are being explored as potential treatments for MUSK-related disorders.

Customer Reviews (3)

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Reviews
11/20/2022

    The MUSK protein's high quality, stellar technical support, and compatibility with diverse experimental approaches make it an optimal choice for meeting my research needs.

    09/01/2017

      Its usage in these techniques is highly praised by scientists worldwide, attesting to its effectiveness and significance in advancing scientific knowledge and understanding.

      01/25/2017

        Its ability to consistently provide accurate and reliable results makes it an invaluable tool for quantifying and detecting specific targets in biological samples.

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