Active Recombinant Human MUSK, GST-tagged
Cat.No. : | MUSK-1434H |
Product Overview : | Recombinant human MUSK (519-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | MUSK is a receptor tyrosine kinase necessary for neuromuscular junction formation. MUSK gene expression is highly regulated during neuromuscular junction and it is involved in intercellular communication present on the surface of cells that are activated by specific protein ligands. MUSK members play a key role in growth and differentiation of those cell types. Agrin signals through MUSK to cluster acetylcholine receptors on the postsynaptic membrane of the neuromuscular junction. DOK7, a MUSK-interacting cytoplasmic protein, is essential for MUSK activation in cultured myotubes. MUSK also plays a critical role in the development of normal blood vessels. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 6.7 nmol/min/mg |
Molecular Mass : | ~63 kDa |
Protein length : | 519 aa-end |
Purity : | >85% |
Applications : | Kinase Assay, Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | MUSK muscle, skeletal, receptor tyrosine kinase [ Homo sapiens ] |
Official Symbol : | MUSK |
Synonyms : | MUSK; muscle, skeletal, receptor tyrosine kinase; muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; MGC126323; MGC126324; |
Gene ID : | 4593 |
mRNA Refseq : | NM_001166280 |
Protein Refseq : | NP_001159752 |
MIM : | 601296 |
UniProt ID : | O15146 |
Chromosome Location : | 9q31.3-q32 |
Function : | ATP binding; PDZ domain binding; nucleotide binding; protein tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity; |
Products Types
◆ Recombinant Protein | ||
MUSK-5457H | Recombinant Human Muscle, Skeletal, Receptor Tyrosine Kinase, GST-tagged | +Inquiry |
MUSK-5760H | Active Recombinant Human MUSK Protein, GST/His-tagged | +Inquiry |
MUSK-2460H | Recombinant Human MUSK protein(31-490 aa), C-His-tagged | +Inquiry |
MUSK-1288M | Recombinant Mouse MUSK Protein, His-SUMO/MYC-tagged | +Inquiry |
MUSK-959H | Recombinant Human MUSK protein(Arg433-Val783), His&GST-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionIn autoimmune myasthenia gravis, immunosuppressive therapies and acetylcholinesterase inhibitors are commonly used to manage symptoms, and some treatments specifically target the immune response against MUSK.
Yes, genetic testing and other diagnostic measures can identify MUSK protein abnormalities early in life, enabling prompt intervention and management.
Yes, diagnostic tests such as genetic testing and antibody assays can be employed to identify MUSK-related disorders.
MUSK protein plays a role in signaling pathways that contribute to muscle regeneration, making it an important factor in tissue repair.
Yes, gene therapy approaches aimed at restoring normal MUSK function are being explored as potential treatments for MUSK-related disorders.
Customer Reviews (3)
Write a reviewThe MUSK protein's high quality, stellar technical support, and compatibility with diverse experimental approaches make it an optimal choice for meeting my research needs.
Its usage in these techniques is highly praised by scientists worldwide, attesting to its effectiveness and significance in advancing scientific knowledge and understanding.
Its ability to consistently provide accurate and reliable results makes it an invaluable tool for quantifying and detecting specific targets in biological samples.
Ask a Question for All MUSK Products
Required fields are marked with *
My Review for All MUSK Products
Required fields are marked with *
Inquiry Basket