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Recombinant Human NFATC1, GST-tagged

Cat.No. : NFATC1-7051H
Product Overview : Recombinant full-length human NFATC1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Description : NFATC1 is a member of the NFAT family of proteins which are Ca2+/calcineurin-responsive transcription factors primarily recognized for their central roles in T lymphocyte activation and cardiac valve development. NFAT consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T-cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to the NFAT family of transcription factors play a central role in inducible gene transcription during immune response. The product of NFATC1 is an inducible nuclear component and functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass : ~125 kDa
Protein length : Full length
Purity : >85%
Applications : Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.2 μg/μl
Gene Name : NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [ Homo sapiens ]
Official Symbol : NFATC1
Synonyms : NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; nuclear factor of activated T-cells, cytoplasmic 1; NF ATC; NFAT2; NFATc; NF-ATc1; NFAT transcription complex cytosolic component; NF-ATC; MGC138448;
Gene ID : 4772
mRNA Refseq : NM_006162
Protein Refseq : NP_006153
MIM : 600489
UniProt ID : O95644
Chromosome Location : 18q23
Pathway : Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem;
Function : DNA binding; FK506 binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II transcription factor binding; mitogen-activated protein kinase p38 binding; protein binding; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; transcription regulatory region DNA binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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