"TYW5" Related Products

Recombinant Human TYW5, His-tagged

Cat.No.: TYW5-7069H
Product Overview: Recombinant human TYW5 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Description: tRNA wybutosine-synthesizing protein 5, also known as TYW5, acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3"-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. TYW5 catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW). OHyW is a derivative of wybutosine found in higher eukaryotes.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl,10% glycerol, 1mM DTT
Molecular Mass: 38.9kDa (338aa)
Protein length: 1-315aa
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAGQHLP VPRLEGVSRE QFMQHLYPQR KPLVLEGIDL GPCTSKWTVD YLSQVGGKKE VKIHVAAVAQ MDFISKNFVY RTLPFDQLVQ RAAEEKHKEF FVSEDEKYYL RSLGEDPRKD VADIRKQFPL LKGDIKFPEF FKEEQFFSSV FRISSPGLQL WTHYDVMDNL LIQVTGKKRV VLFSPRDAQY LYLKGTKSEV LNIDNPDLAK YPLFSKARRY ECSLEAGDVL FIPALWFHNV ISEEFGVGVN IFWKHLPSEC YDKTDTYGNK DPTAASRAAQ ILDRALKTLA ELPEEYRDFY ARRMVLHIQD KAYSKNSE
Purity: >95% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml
Gene Name: TYW5 tRNA-yW synthesizing protein 5 [ Homo sapiens ]
Official Symbol: TYW5
Synonyms: TYW5; tRNA-yW synthesizing protein 5; C2orf60, chromosome 2 open reading frame 60; tRNA wybutosine-synthesizing protein 5; FLJ37953; tRNA yW-synthesizing enzyme 5; jmjC domain-containing protein C2orf60; hTYW5; C2orf60; MGC70509;
Gene ID: 129450
mRNA Refseq: NM_001039693
Protein Refseq: NP_001034782
UniProt ID: A2RUC4
Chromosome Location: 2q33.1
Function: iron ion binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; protein homodimerization activity; tRNA binding;

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