Mouse Anti-TNFRSF6B Monoclonal Antibody


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Mouse Anti-TNFRSF6B Monoclonal Antibody

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Cat.No. : DMABT-H18387
Product Overview : Mouse Anti-TNFRSF6B Monoclonal Antibody
Antigen Description : The DcR3 protein is a soluble member of the TNF receptor superfamily containing four TNF receptor domains with an approximate molecular weight of 35 kD. DcR3, also known as Decoy receptor 3, TR6, M68, can be secreted by monocytes and myeloid-derived dendritic cells following exposure to bacterial antigens. DcR3 is overexpressed in tumors including lung and colon cancers, gliomas, and pancreatic cancers and can be detected in the serum of cancer patients. DcR3 can also be found in the cytoplasm and endoplasmic reticulum in some cell types. This protein competes for ligand binding with cell surface receptor and can inhibit their signaling. DcR3 has been shown to bind the ligands FasL, LIGHT, and TNF like molecule2(TL1A) to inhibit binding to the cell surface receptors Fas, HVEM and LT-beta R, and death receptor4(DR3), respectively.
Target : TNFRSF6B
Immunogen : Human DcR3 Fc protein
Host : Mouse
Isotype : IgG1, kappa
species : Human
Clone : C09-46
Conjugation : N/A
Applications : WB,IP,IHC,ELISA
Preparation : The antibody was purified by affinity chromatography.
Usage recommendation : Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤1.0 μg per 106cells in 100 μl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Concentration : 0.5 mg/ml
Storage : The antibody solution should be stored undiluted at 4 °C.
Size : 100 μg
Gene Name : TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy [ Homo sapiens ]
Official Symbol : TNFRSF6B
Synonyms : TNFRSF6B; tumor necrosis factor receptor superfamily, member 6b, decoy; tumor necrosis factor receptor superfamily member 6B; DcR3; DCR3; M68; TR6; decoy receptor 3; decoy receptor for Fas ligand; M68E; DJ583P15.1.1;
Gene ID : 8771
mRNA Refseq : NM_003823
Protein Refseq : NP_003814
MIM : 603361
UniProt ID : O95407
Chromosome Location : 20q13.3
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : protein binding; receptor activity;

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