Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human Bone Morphogenetic Protein Receptor, Type IA

Cat.No. : BMPR1A-4130H
Product Overview : BMPR1A Human Recombinant produced in HEK-293 cells is a single, glycosylated, polypeptide chain containing 369 amino acids with a molecular weight of 43.7 kDa though on SDS-PAGE migrates at about 50 kDa due to the glycosilation. The BMPR1A is purified by proprietary chromatographic techniques.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : BMPR1A-4130H
Description : The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily.
Source : Human
Host : HEK293-F Cells.
Form : The BMPR1A protein was lyophilized from a 0.2µm filtered solution containing no additives or preservatives.
Purity : Greater than 95.0% as determined by SDS-PAGE.
Bio-activity : The biological activity of human BMPR1A is determined by its ability to inhibit human BMP-4 induction of alkaline phosphatase in the mouse chondrogenic cell line ATDC5. The observed ED50 range is from 0.1 to 0.3 µg/ml in the presence of 30ng/ml of recombinant human BMP-4 protein.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility : It is recommended to reconstitute the lyophilized BMPR1A in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Amino acid sequence : QNLDSMLHGT GMKSDSDQKK SENGVTLAPE DTLPFLKCYC SGHCPDDAIN NTCITNGHCF AIIEEDDQGE TTLASGCMKY EGSDFQCKDS PKAQLRRTIE CCRTNLCNQY LQPTLPPVVI GPFFDGSIRE NLYFQGGSGT KLDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH GDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK.
Storage : Lyophilized BMPR1A although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMPR1A should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : BMPR1A bone morphogenetic protein receptor, type IA [ Homo sapiens ]
Official Symbol : BMPR1A
Synonyms : BMPR1A; bone morphogenetic protein receptor, type IA; ALK3; SKR5; CD292; ACVRLK3; 10q23del; OTTHUMP00000020014; activin A receptor, type II-like kinase 3; serine/threonine-protein kinase receptor; Bone morphogenetic protein receptor type-1A; EC 2.7.11.30; Serine/threonine-protein kinase receptor R5; Activin receptor-like kinase 3; ALK-3
Gene ID : 657
mRNA Refseq : NM_004329
Protein Refseq : NP_004320
MIM : 601299
UniProt ID : P36894
Chromosome Location : 10q22.3
Pathway : Cytokine-cytokine receptor interaction; TGF-beta signaling pathway; Signaling by BMP
Function : ATP binding; SMAD binding; magnesium ion binding; nucleotide binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor activity; transferase activity; transforming growth factor beta receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (6)

Ask a question
What disease might abnormal BMPR1A levels suggest? 11/20/2022

Abnormal levels of BMPR1A may suggest skeletal dysplasia, tumors, etc., but its specificity and sensitivity need to be further studied.

Is there a mutation type of BMPR1A? 10/12/2022

The types of mutations in BMPR1A include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

How are mutations in BMPR1A detected and analyzed? 01/05/2022

Mutations in BMPR1A can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

How to study the regulatory mechanism of BMPR1A? 01/03/2022

Studying the regulatory mechanism of BMPR1A requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What are the applications of BMPR1A in medical treatment? 03/10/2020

BMPR1A can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting BMPR1A, such as gene therapy or modulating its expression, are also being studied.

What diseases can BMPR1A deficiency or aberrant expression cause? 01/21/2020

Deficiency or abnormal expression of BMPR1A may be related to some skeletal dysplasia diseases, tumors, etc.

Customer Reviews (3)

Write a review
Reviews
11/06/2021

    The enzyme activity of this protein reached the expected level and was able to play a role in the specific reaction.

    10/20/2021

      When experimenting with this protein, stable and repeatable results can be obtained.

      03/08/2021

        This product has strict quality control and complies with relevant industry standards.

        Ask a Question for All BMPR1A Products

        Required fields are marked with *

        My Review for All BMPR1A Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends