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Recombinant Mouse Chemokine (C-C motif) Ligand 5

Cat. No.: Ccl5-259M
Product Overview: Rantes Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 68 amino acids and having a molecular mass of 7876 Dalton. The Mouse Rantes is purified by proprietary chromatographic techniques.
Description: Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. It has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e. IL-2 and IFN-?) that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. It is also a HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans.
Source: Mouse
Host: Escherichia Coli
Form: Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.
Purity: Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Bio-activity: The activity is determined by the ability to chemoattract total human lymphocytes and murine T-cells at a concentration between 1-10ng/ml.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility: It is recommended to reconstitute the lyophilized Rantes in sterile 18Mμ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Amino acid sequence: SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS.
Storage: Lyophilized Mouse Rantes although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CCL5 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Pathways: Chagas disease (American trypanosomiasis); Chemokine receptors bind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-like receptors); Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway; G alpha (i) signalling events; GPCR downstream signaling;
Gene Name: Ccl5 chemokine (C-C motif) ligand 5 [ Mus musculus ]
Official Symbol: Ccl5
Synonyms: Ccl5; chemokine (C-C motif) ligand 5; SISd; Scya5; RANTES; TCP228; MuRantes; C-C motif chemokine 5; SIS-delta; OTTMUSP00000000943; small inducible cytokine A5; small-inducible cytokine A5; T-cell-specific protein RANTES; D17S136E; OTTHUMP00000197106; SCYA5; beta-chemokine RANTES; MGC17164; eoCP; regulated upon activation, normally T-expressed, and presumably secreted; small inducible cytokine A5(RANTES); small inducible cytokine subfamily A (Cys-Cys), member 5; Eosinophil chemotactic cytokine; T-cell specific protein p288; Small-inducible cytokine A5; EoCP
Gene ID: 20304
mRNA Refseq: NM_013653
Protein Refseq: NP_038681
UniProt ID: P30882
Chromosome Location: 11 C; 11 47.4 cM
Function: CCR1 chemokine receptor binding; CCR5 chemokine receptor binding; chemoattractant activity; chemokine activity; chemokine receptor antagonist activity; chemokine receptor binding; cytokine activity; heparin binding; protein homodimerization activity; protein self-association; receptor signaling protein tyrosine kinase activator activity

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