Recombinant Human CCL11

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Recombinant Human CCL11

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Cat. No. : CCL11-172H
Product Overview : Human CCL11 (P51671, 1 a.a.-97 a.a.) full-length recombinant protein. expressed in Escherichia coli.
Description : Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin-1. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3. The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17.
Sequence : MKVSAALLWL LLIAAAFSPQ GLAGPASVPT TCCFNLANRK IPLQRLESYR RITSGKCPQK AVIFKTKLAK DICADPKKKW VQDSMKYLDQ KSPTPKP
Theoretical MW (kDa) : 9
Form : Liquid
Preparation Method : E. coli expression system
Purity : > 97% by SDS-PAGE and HPLC
Endotoxin Level : < 0.1 ng/ug (1 EU/ug)
Activity : Activity was determined by the ability to induce chemotaxis of purified eosinophils at concentrations ranging between 50-100 ng/mL.
Application : Functional Study; SDS-PAGE
Storage Buffer : In 100 mM NaCl, 20 mM Tris (0.1 M glycerol) pH 8.0
Storage : Store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing.
Unitprot ID : P51671
Pathways : Asthma; Chemokine signaling pathway; Cytokine-cytokine receptor interaction
PDBrendering based on 1eot. :

Gene Name : CCL11 chemokine (C-C motif) ligand 11 [ Homo sapiens ]
Official Symbol : CCL11
Synonyms : CCL11; chemokine (C-C motif) ligand 11; C-C motif chemokine 11; eotaxin; eotaxin-1; Eosinophil chemotactic protein; MGC22554; Small-inducible cytokine A11; small inducible cytokine A11; SCYA11; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
Gene ID : 6356
mRNA Refseq : NM_002986
Protein Refseq : NP_002977
MIM : 601156
Chromosome Location : 17q21.1-q21.2
Function : chemokine activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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