"Csf3" Related Products

Recombinant Mouse Colony Stimulating Factor 3 (Granulocyte)

Cat. No. : Csf3-273M
Product Overview : Recombinant Mouse Csf3 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 179 amino acids and having a molecular mass of 19 kDa.
Description : A glycoprotein containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, Csf3 is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. The synthesis of Csf3 can be induced by bacterial endotoxins , TNF , Interleukin-1 and GM-CSF . Prostaglandin E2 inhibits the synthesis of Csf3.
Species : Mouse
Source : E.coli
Form : Lyopohilized with no additives.
Purity : Purity Greater than 98% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Bio-activity : Mouse recombinant Csf3 is fully biologically active when compared to standard. The ED50, calculated by the dose-dependant proliferation of mouse M-NFS-60 cells, is 0.04 ng/ml.
Physical Appearance : Sterile Filtered white lyophilized (freeze-dried) powder.
Solubility : Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg"s/ml, which can be further diluted into other aqueous solutions.
Purity Greater than 98% as determined by : Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Protein Content determined by : UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Storage : Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Pathways : Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway
Crystal structure of3 molecules of human Csf3. From PDB 1rhg :

Gene Name : Csf3 colony stimulating factor 3 (granulocyte) [ Mus musculus ]
Official Symbol : Csf3
Synonyms : Csf3; colony stimulating factor 3 (granulocyte); Csfg; G-CSF; MGI-IG; colony stimulating factor 3; OTTMUSP00000006785
Gene ID : 12985
mRNA Refseq : NM_009971
Protein Refseq : NP_034101
UniProt ID : P09920
Chromosome Location : 11 D; 11 57.0 cM
Function : Cytokine activity; Growth factor activity

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