Active Recombinant Human FK506 Binding Protein 2, 13kDa

• Cat.No.: FKBP2-1288H
• Product Overview: FKBP2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 122 amino acids (22-142 a.a.) and having a molecular mass of 13.4 kDa. The FKBP2 is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: FKBP2-1288H
• Description: FKBP2 is part of the immunophilin protein family, which takes part in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP2 is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. FKBP2 functions as an ER chaperone and as a component of membrane cytoskeletal scaffolds.
• Source: Human
• Host: Escherichia Coli.
• Form: The FKBP2 solution contains 20mM Tris-HCl pH-8, 1mM DTT, and 10% glycerol.
• Purity: Greater than 90% as determined by SDS-PAGE.
• Bio-activity: Specific activity is > 150 nmoles/min/ug, and is defined as the amount of enzyme that cleave 1umole of suc-AAFP-pNA per minute at 1C in Tris-Hcl pH8.0 using chymotrypsin.
• Physical Appearance: Sterile Filtered clear colorless solution.
• Amino acid sequence: MATGAEGKRK LQIGVKKRVD HCPIKSRKGD VLHMHYTGKL EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE KRKLVIPSEL GYGERGAPPK IPGGATLVFE VELLKIERRT EL.
• Storage: FKBP2 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days. Please avoid freeze-thaw cycles.

Gene Information

• Gene Name: FKBP2 FK506 binding protein 2, 13kDa [ Homo sapiens ]
• Official Symbol: FKBP2
• Synonyms: FKBP2; FK506 binding protein 2, 13kDa; PPIase; FKBP-13; FKBP2; peptidyl-prolyl cis-trans isomerase FKBP2; FKBP-2; rotamase; 13 kDa FKBP; PPIase FKBP2; proline isomerase; immunophilin FKBP13; rapamycin-binding protein; 13 kDa FK506-binding protein; EC 5.2.1.8; FK506-binding protein 2; Rotamase; Immunophilin FKBP13; 13 kDa FK506-binding protein; Peptidyl-prolyl cis-trans isomerase; rapamycin-binding protein
• Gene ID: 2286
• mRNA Refseq: NM_001135208
• Protein Refseq: NP_001128680
• MIM: 186946
• UniProt ID: P26885
• Chromosome Location: 11q13.1-q13.3
• Function: FK506 binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding