"IL4" Related Products

Recombinant Human IL4 (25-153aa), Met tagged

Cat. No.: IL4-030E
Product Overview: Recombinant Human IL4 (His25 ­ Ser153, with an N­terminal Met) was expressed in E. coli and produced using non­animal reagent in an animal­free laboratory.
Description: Interleukin­4 (IL­4), also known as B cell­stimulatory factor­1, is a monomeric, approximately 13 kDa ­ 18 kDa Th2 cytokine that shows pleiotropic effects during immune responses. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four μ­helix structure. IL­4 is primarily expressed by Th2­biased CD4+ T cells, mast cells, basophils, and eosinophils . It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL­4 plays a dominant role in the development of allergic inflammation and asthma.
Source: E. coli
N­terminal Sequence Analysi: Met
Molecular Mass: 14 kDa
Activity: Measured in a cell proliferation assay using TF­1 human erythroleukemic cells. The ED50 for this effect is typically 0.05 ­ 0.2 ng/mL.
Endotoxin Leve: <1.0 EU per 1 μg of the protein by the LAL method.
Purity: >97%, by SDS­PAGE under reducing conditions and visualized by silver stain.
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS. See Certificate of Analysis for details.
Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage: Use a manual defrost freezer and avoid repeated freeze­thaw cycles. 1. 12 months from date of receipt, ­20 to ­70 °C as supplied. 2. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3. 3 months, ­20 to ­70 °C under sterile conditions after reconstitution.
Unitprot ID: P05112
Gene Name: IL4 interleukin 4 [ Homo sapiens ]
Official Symbol: IL4
Synonyms: IL4; interleukin 4; BSF1; IL-4; BCGF1; BSF-1; BCGF-1; MGC79402; interleukin-4; binetrakin; pitrakinra; B cell growth factor 1; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1
Gene ID: 3565
mRNA Refseq: NM_000589
Protein Refseq: NP_000580
MIM: 147780
Chromosome Location: 5q31.1
Pathway: CD40/CD40L signaling; Calcium signaling in the CD4+ TCR pathway; Fc epsilon RI signaling pathway; IL-4 signaling Pathway; Jak-STAT signaling pathway; T cell receptor signaling pathway; Notch signaling pathway
Function: cytokine activity; growth factor activity; interleukin-4 receptor binding; protein binding

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