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Recombinant Human Lectin, Galactoside-Binding, Soluble, 3

Cat. No.: LGALS3-452H
Product Overview: LGALS3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 250 amino acids and having a molecular mass of 26 kDa. The LGALS3 is purified by proprietary chromatographic techniques.
Description: Galectin-3 mediates with the alpha-3, beta-1 integrin the stimulation by cspg4 of endothelial cells migration. Galectin-3 plays an necessary part during the acquisition of vasculogenic mimicry and angiogenic properties associated with melanoma progression. LGALS3 overexpression is highly expressed in early stages of papillary carcinoma, and its expression intensity declines during tumor progression.
Source: Human
Host: Escherichia Coli.
Form: The Galectin-3 protein was lyophilized from a concentrated (1mg/ml) containing 10mM sodium phosphate buffer, pH-7.5 and 50mM NaCl.
Purity: Greater than 97.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Bio-activity: Determined by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2 µg/ml with a peak response obtained at 220 µg/ml.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility: It is recommended to reconstitute the lyophilized LGALS3 in sterile 18Mμ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Amino acid sequence: ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GAGGYPGASY PGAYPGQAPP GAYPGQAPPG AYHGAPGAYP GAPAPGVYPG PPSGPGAYPS SGQPSAPGAY PATGPYGAPA GPLIVPYNLP LPGGVVPRML ITILGTVKPN ANRIALDFQR GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GREERQSVFP FESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHRVKKLNEI SKLGISGDID LTSASYTMI.
Storage: Lyophilized Galectin-3 Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Galectin-3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name: LGALS3 lectin, galactoside-binding, soluble, 3 [ Homo sapiens ]
Official Symbol: LGALS3
Synonyms: LGALS3; lectin, galactoside-binding, soluble, 3; Galectin-3; beta-galactosides-binding lectin; lectin, galactoside-binding, soluble, 3 (galectin 3)
Gene ID: 404021
UniProt ID: P38486

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