"SH2D1A" Related Products

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Recombinant Human SH2 Domain Containing 1A, His-tagged

Cat. No.: SH2D1A-4591H
Product Overview: SH2D1A Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 148 amino acids (1-128 a.a.) and having a molecular mass of 16.3kDa. The SH2D1A is purified by proprietary chromatographic techniques.
Description: SH2D1A acts as an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association. The SH2D1A protein is expressed at a high level in the thymus and the lung, with a lower level of expression in the spleen and the liver. The SH2D1A protein contains an SH2 domain and a short tail. SH2D1A has a key role in the bidirectional stimulation of T and B cells. Defects in the SH2D1A gene cause the X-linked lymphoproliferative disease (XLPD), aka Duncan disease. The XLPD is distinguished by a rare congenital immunodeficiency following an EBV infection (Epstein-Barr virus).
Source: Human
Host: Escherichia Coli.
Form: The SH2D1A solution (1 mg/ml) contains 20mM Tris-HCl Buffer (pH 7.5), 1mM DTT and 10% Glycerol.
Purity: Greater than 95.0% as determined by SDS-PAGE.
Physical Appearance: Sterile Filtered colorless solution.
Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP.
Storage: SH2D1A should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name: SH2D1A SH2 domain containing 1A [ Homo sapiens ]
Official Symbol: SH2D1A
Synonyms: SH2D1A; LYP; SAP; XLP; DSHP; EBVS; IMD5; XLPD; MTCP1; FLJ18687; FLJ92177; SAP/SH2D1A; SH2 domain-containing protein 1A; OTTHUMP00000023976; OTTHUMP00000226563; SLAM-associated protein; Duncan disease SH2-protein; T cell signal transduction molecule SAP; SLAM associated protein/SH2 domain protein 1A; signaling lymphocyte activation molecule-associated protein; signaling lymphocytic activation molecule-associated protein
Gene ID: 4068
mRNA Refseq: NM_001114937
Protein Refseq: NP_001108409
MIM: 300490
UniProt ID: O60880
Chromosome Location: Xq25
Pathway: Direct p53 effectors; Measles; Natural killer cell mediated cytotoxicity
Function: SH3/SH2 adaptor activity

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