Recombinant Human Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding), His-Fc-Tagged
Cat.No. : | TNFSF11-313H |
Product Overview : | The monoclonal antibody to RANKL is a human IgG2 monoclonal antibody, have affinity and specificity with human RANKL (receptor activator of nuclear factor kappa-B ligand). 147 kDa Molecular weight, is genetically engineered mammalian (Chinese hamster ovary) cell production. |
- Specification
- Gene Information
- Related Products
Cat. No. : | TNFSF11-313H |
Description : | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |
Source : | Human |
Host : | Chinese Hamster Ovary |
Form : | Sterilized PBS, pH7.4 |
Purity : | > 95%; |
Endotoxin : | <1.0EU/10mg(LAL gel) |
Stability : | 4μ: 6months. -20μ: 1 year, avoiding repeated freezing and thawing. |
Predicted N terminal : | H-strand: EVQLLESGGG; L-strand: EIVLTQSPGT |
Molecular Mass : | OPGL monoclonal antibody consists of 1326 Amino acids, Molecular Mass is 147KDa. |
Storage : | 4μ for 6 months; -20 μ for 1 year, Avoiding repeated freezing and thawing. |
Gene Name : | TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 [ Homo sapiens ] |
Official Symbol : | TNFSF11 |
Synonyms : | TNFSF11; tumor necrosis factor (ligand) superfamily, member 11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; tumor necrosis factor ligand superfamily, member 11; OTTHUMP00000178585; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; CD254 antigen; Osteoprotegerin ligand |
Gene ID : | 8600 |
mRNA Refseq : | NM_003701 |
Protein Refseq : | NP_003692 |
MIM : | 602642 |
UniProt ID : | O14788 |
Chromosome Location : | 13q14 |
Pathway : | Cytokine-cytokine receptor interaction |
Function : | cytokine activity; protein binding; receptor activity; tumor necrosis factor receptor binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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