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Recombinant Thioredoxin, His-tagged

Cat. No.: TXN-4662H
Product Overview: Thioredoxin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 125 amino acids (1-105 a.a.) and having a molecular mass of 13.9 kDa. TXN protein is fused to a 20 amino acid His-Tag at N-terminus and purified by standard chromatography.
Description: Thioredoxins are small disulphide-containing redox proteins (within the conserved Cys-Gly-Pro-Cys active site) that have been found in all the kingdoms of living organisms. Thioredoxin contains a single disulfide active site and serves as a general protein disulphide oxidoreductase. Thioredoxins are involved in the first unique step in DNA synthesis. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of two cysteine thiol groups to a disulphide, accompanied by the transfer of two electrons and two protons. The net result is the covalent interconversion of a disulphide and a dithiol. It has been suggested that thioredoxin may catalyze the formation of correct disulfides during protein folding because of its ability to act as an efficient oxidoreductant. Trx also provides control over a number of transcription factors affecting cell proliferation and death through a mechanism referred to as redox regulation.
Source: Human
Host: Escherichia Coli.
Form: TXN1 solution containing 1x PBS pH 7.4.
Purity: Greater than 95.0% as determined by SDS-PAGE.
Bio-activity: Specific activity is 7-10 A650/min/mg, obtained by measuring the increase of insulin precipitation in absorbance at 650 nm resulting from the reduction of insulin.
Physical Appearance: Sterile filtered colorless solution.
Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV.
Storage: Thioredoxin human although stable at 4ºC for 1 week, should be stored desiccated below -18ºC. Please prevent freeze thaw cycles.
Pathways: Nucleotide metabolism
Gene Name: TXN thioredoxin [ Homo sapiens ]
Official Symbol: TXN
Synonyms: TXN; MGC61975; TRX; ADF; DKFZp686B1993; MGC61975; OTTHUMP00000021892; SASP; TRDX; TRX1; Trx; thioredoxin; ATL-derived factor; Surface-associated sulphydryl protein
Gene ID: 7295
mRNA Refseq: NM_003329
Protein Refseq: NP_003320
MIM: 187700
UniProt ID: P10599
Chromosome Location: 9q31
Function: protein binding

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