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Active Recombinant Thioredoxin, His-tagged

Cat.No. : TXN-4662H
Product Overview : Thioredoxin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 125 amino acids (1-105 a.a.) and having a molecular mass of 13.9 kDa. TXN protein is fused to a 20 amino acid His-Tag at N-terminus and purified by standard chromatography.
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Cat. No. : TXN-4662H
Description : Thioredoxins are small disulphide-containing redox proteins (within the conserved Cys-Gly-Pro-Cys active site) that have been found in all the kingdoms of living organisms. Thioredoxin contains a single disulfide active site and serves as a general protein disulphide oxidoreductase. Thioredoxins are involved in the first unique step in DNA synthesis. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of two cysteine thiol groups to a disulphide, accompanied by the transfer of two electrons and two protons. The net result is the covalent interconversion of a disulphide and a dithiol. It has been suggested that thioredoxin may catalyze the formation of correct disulfides during protein folding because of its ability to act as an efficient oxidoreductant. Trx also provides control over a number of transcription factors affecting cell proliferation and death through a mechanism referred to as redox regulation.
Source : Human
Host : Escherichia Coli.
Form : TXN1 solution containing 1x PBS pH 7.4.
Purity : Greater than 95.0% as determined by SDS-PAGE.
Bio-activity : Specific activity is 7-10 A650/min/mg, obtained by measuring the increase of insulin precipitation in absorbance at 650 nm resulting from the reduction of insulin.
Physical Appearance : Sterile filtered colorless solution.
Amino acid sequence : MGSSHHHHHH SSGLVPRGSH MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV.
Storage : Thioredoxin human although stable at 4ºC for 1 week, should be stored desiccated below -18ºC. Please prevent freeze thaw cycles.
Pathways : Nucleotide metabolism
Gene Name : TXN thioredoxin [ Homo sapiens ]
Official Symbol : TXN
Synonyms : TXN; MGC61975; TRX; ADF; DKFZp686B1993; MGC61975; OTTHUMP00000021892; SASP; TRDX; TRX1; Trx; thioredoxin; ATL-derived factor; Surface-associated sulphydryl protein
Gene ID : 7295
mRNA Refseq : NM_003329
Protein Refseq : NP_003320
MIM : 187700
UniProt ID : P10599
Chromosome Location : 9q31
Function : protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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10/17/2022

    Their team of experts is readily available to address any concerns or queries I may have regarding the TXN protein.

    10/04/2016

      The TXN protein offered by the manufacturer excels in its quality and is an excellent match for my experimental requirements.

      05/29/2016

        Their team of experts is readily available to address any queries or concerns I may have regarding the TXN protein.

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