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Recombinant Human Thioredoxin Reductase 1

Cat. No.: TXNRD1-1117H
Product Overview: HumanTXNRD1 (161 a.a. - 647 a.a.) partial recombinant protein with His tagexpressed in E. coli.
Description: TXNRD1is an enzyme that in humans is encoded by the TXNRD1 gene. This gene encodesa member of the family of pyridine nucleotide oxidoreductases. This proteinreduces thioredoxins as well as other substrates, and plays a role inselenium metabolism and protection against oxidative stress. The functionalenzyme is thought to be a homodimer which uses FAD as a cofactor.
Source: E. coli
Species: Human
Form: Liquid
Molecular Weight: 55.7 kDa
Purity: >95% by SDS-PAGE.
Activity: Specificactivity is 0.48-0.6 units/mL, and was measured in a coupled assay with DTNBand NADPH. The amount of TNB generated by NADPH was measured in absorbance at412 nm.
Buffer: In PBS, pH7.4 (10% glycerol).
Quality ControlTesting: Loading 3 ugprotein in 15% SDS-PAGE.
Purification: ConventionalChromatography.
Concentration: 0.5 mg/mL
Sequences of aminoacids: MGSSHHHHHH SSGLVPRGSH MYDYDLIIIG GGSGGLAAAK EAAQYGKKVMVLDFVTPTPL GTRWGLGGTC VNVGCIPKKL MHQAALLGQA LQDSRNYGWK VEETVKHDWD RMIEAVQNHI GSLNWGYRVALREKKVVYEN AYGQFIGPHR IKATNNKGKE KIYSAERFLI ATGERPRYLG IPGDKEYCIS SDDLFSLPYCPGKTLVVGAS YVALECAGFL AGIGLDVTVM VRSILLRGFD QDMANKIGEH MEEHGIKFIR QFVPIKVEQIEAGTPGRLRV VAQSTNSEEI IEGEYNTVML AIGRDACTRK IGLETVGVKI NEKTGKIPVT DEEQTNVPYIYAIGDILEDK VELTPVAIQA GRLLAQRLYA GSTVKCDYEN VPTTVFTPLE YGACGLSEEK AVEKFGEENIEVYHSYFWPL EWTIPSRDNN KCYAKIICNT KDNERVVGFH VLGPNAGEVT QGFAAALKCG LTKKQLDSTIGIHPVCAEVF TTLSVTKRSG ASILQAGC
Storage: Storeat 4°C for 1-2 weeks. For long term storage store at -20°C or -80°C. Aliquotto avoid repeated freezing and thawing.
Gene Name: TXNRD1 thioredoxinreductase 1 [ Homo sapiens ]
Official Symbol: TXNRD1
Synonyms: TXNRD1;thioredoxin reductase 1; TR; TR1; TXNR; TRXR1; GRIM-12; MGC9145; thioredoxinreductase 1, cytoplasmic; oxidoreductase; thioredoxin reductase TR1;thioredoxin reductase GRIM-12; KM-102-derived reductase-like factor; geneassociated with retinoic and IFN-induced mortality 12 protein; gene associatedwith retinoic and interferon-induced mortality 12 protein; EC 1.8.1.9; EC1.8.1; OTTHUMP00000232986; OTTHUMP00000232988; OTTHUMP00000232990;OTTHUMP00000232992; OTTHUMP00000232993; OTTHUMP00000232996;OTTHUMP00000232997; OTTHUMP00000232999
Gene ID: 7296
mRNA Refseq: NM_003330
Protein Refseq: NP_003321
MIM: 601112
UniProt ID: Q16881
Chromosome Location: 12q23-q24.1
Pathway: Fatty acid triacylglycerol and ketone bodymetabolism; Metabolism; Metabolism of lipids and lipoproteins; Metabolism ofnucleotides; Oxidative Stress; PPARA Activates Gene Expression; Pyrimidinemetabolism; Regulation of Lipid Metabolism by Peroxisomeproliferator-activated receptor alpha (PPARalpha); Selenium Metabolism andSelenoproteins; Selenium Pathway; Selenocompound metabolism; Synthesis andinterconversion of nucleotide di- and triphosphates; selenium; thioredoxinpathway
Function: NADP binding; electron carrier activity;flavin adenine dinucleotide binding; oxidoreductase activity; proteindisulfide oxidoreductase activity; thioredoxin-disulfide reductase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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