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Recombinant Human S100A12, His-tagged

Cat. No.: S100A12-3721H
Product Overview: Total 101 AA. MW: 11.63 kDa (calculated). N-Terminal His-tag, 10 extra AA (highlighted).
Description: Protein S100-A12 is a protein that in humans is encoded by the S100A12 gene. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.
Source: E. coli
Species: Human
Form: Filtered (0,4 μm) and lyophilized in 0.5 mg/mL in 20mM TRIS, 50mM NaCl, pH 7.5.
Reconstitution: Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Applications: Western blotting
Quality Control Test: BCA to determine quantity of the protein; SDS PAGE to determine purity of the protein
Sequences of amino acids: MKHHHHHHAS TKLEEHLEGI VNIFHQYSVR KGHFDTLSKG ELKQLLTKEL ANTIKNIKDK AVIDEIFQGL DANQDEQVDF QEFISLVAIA LKAAHYHTHK E
Storage: Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C.
Pathways: Activated TLR4 signalling; Advanced glycosylation endproduct receptor signaling; Innate Immunity Signaling; MyD88 cascade initiated on plasma membrane; MyD88 dependent cascade initiated on endosome; MyD88-independent cascade initiated on plasma membrane; NFkB and MAP kinases activation mediated by TLR4 signaling repertoire; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways; Signaling in Immune system; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TRAF6 Mediated Induction of proinflammatory cytokines; TRAF6 mediated NF-kB activation; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; Toll Like Receptor 2 Cascade; Toll Like Receptor 3 (TLR3) Cascade
Gene Name: S100A12 S100 calcium binding protein A12 [ Homo sapiens ]
Official Symbol: S100A12
Synonyms: S100A12; S100 calcium binding protein A12; p6; CAGC; CGRP; MRP6; CAAF1; ENRAGE; protein S100-A12; EN-RAGE; calgranulin C; calgranulin-C; OTTHUMP00000015332; neutrophil S100 protein; calcium-binding protein in amniotic fluid 1; S100 calcium-binding protein A12 (calgranulin C); extracellular newly identified RAGE-binding protein; S100 calcium binding protein A12 (calgranulin C); Protein S100-A12; Calcium-binding protein in amniotic fluid 1; Calgranulin-C; Extracellular newly identified RAGE-binding protein; Neutrophil S100 protein; S100 calcium-binding protein A12; Calcitermin
Gene ID: 6283
mRNA Refseq: NM_005621
Protein Refseq: NP_005612
MIM: 603112
UniProt ID: P80511
Chromosome Location: 1q21
Function: RAGE receptor binding; RAGE receptor binding; calcium ion binding; protein binding; zinc ion binding

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