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Recombinant Human RGN, His-tagged

Cat. No.: RGN-3642H
Product Overview: Recombinant human RGN protein, fused to His-tag at N-terminus, was expressed in E.coli (1-299 aa).
Description: RGN (Regucalcin) belongs to the SMP-30/CGR1 family. This protein is Ca (2+)-binding protein that does not contain EF-hand motif of Ca (2+)-binding domain. RGN plays a pivotal role in the keep of intracellular Ca2+ homeostasis due to activating Ca2+ pump enzymes in the plasma membrane (basolateral membrane), microsomes (endoplasmic reticulum) and mitochondria of many cells. Also, it plays a multifunctional role in the regulation of cell functions in liver, kidney cortex, heart and brain and a suppressor protein for cell signaling systems in many cell types.
Form: Liquid. In 20mM Tris-HCl, pH8.0, 2M Urea, 20%Glycerol
Molecular Weight: 35.4kDa (319aa)
Purity: > 85% by SDS - PAGE
Concentration: 0.5mg/ml (determined by Bradford assay)
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MSSIKIECVL PENCRCGESP VWEEVSNSLL FVDIPAKKVC RWDSFTKQVQ RVTMDAPVSS VALRQSGGYV ATIGTKFCAL NWKEQSAVVL ATVDNDKKNN RFNDGKVDPA GRYFAGTMAE ETAPAVLERH QGALYSLFPD HHVKKYFDQV DISNGLDWSL DHKIFYYIDS LSYSVDAFDY DLQTGQISNR RSVYKLEKEE QIPDGMCIDA EGKLWVACYN GGRVIRLDPV TGKRLQTVKL PVDKTTSCCF GGKNYSEMYV TCARDGMDPE GLLRQPEAGG IFKITGLGVK GIAPYSYAG
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: Ascorbate and aldarate metabolism; Metabolic pathways; Pentose phosphate pathway
Gene Name: RGN regucalcin (senescence marker protein-30) [ Homo sapiens ]
Official Symbol: RGN
Synonyms: RGN; RC; GNL; SMP30; regucalcin (senescence marker protein-30); regucalcin; SMP-30; gluconolactonase; OTTHUMP00000023195; OTTHUMP00000023196; senescence marker protein 30; senescence marker protein-30; EC 3.1.1.17; Gluconolactonase
Gene ID: 9104
mRNA Refseq: NM_004683
Protein Refseq: NP_004674
MIM: 300212
UniProt ID: Q15493
Chromosome Location: Xp11.3
Function: calcium ion binding; enzyme regulator activity; gluconolactonase activity; hydrolase activity; zinc ion binding

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