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Recombinant Human Chemokine (C-C Motif) Ligand 20

Cat. No.: CCL20-11H
Product Overview: Recombinant Human MIP-3 alpha/CCL20 produced inE. coliis a single, non-glycosylated polypeptide chain containing 70 amino acids and having a molecular mass of 8.0 kDa.
Description: MIP-3 alpha/CCL20, also known as LARC (Liver and Activation-regulated Chemokine) and as Exodus, is a CC chemokine that is expressed in the liver, lymph nodes, appendix, PBL and lung and can signal through the CCR6 receptor. MIP-3 alpha is chemotactic towards lymphocytes and dendritic cells. Additionally, it promotes the adhesion of memory CD4+ T cells and inhibits colony formation of bone marrow myeloid immature progenitors.
Purity: >97% by SDS-PAGE and HPLC analyses.
Formulation: Lyophilized from a 0.2μm filtered concentrated (0.5mg/ml) solution in 20mM PB, pH 7.4, 100mM NaCl.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Specific Activity: Fully biologically active when compared to standard. Determined by its ability to chemoattract human T lymphocytes using a concentration range of 10.0 -50.0 ng/ml.
Endotoxin: Less than 1EU/μg of rHuMIP-3a/CCL20 as determined by LAL method.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Storage: This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Gene Name: CCL20
Synonyms: CKb4; LARC; exodus-1; MIP-3-alpha ; ST38; MIP3A; MIP-3a; SCYA20; Beta chemokine exodus-1; C-C motif chemokine 20 precursor; chemokine (C-C motif) ligand 20; CC chemokine LARC; CCL20_HUMAN; Human mRNA for CC chemokine LARC precursor, complete cds; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; Small-inducible cytokine A20; chemokine (C-C motif) ligand 20; small inducible cytokine subfamily A (Cys-Cys), member 20; CCL20
Gene ID: 6364
mRNA Refseq: NM_001130046
Protein Refseq: NP_001123518
MIM: 601960
UniProt ID: P78556
Chromosome Location: 2q33-q37
Pathway: Cytokine-cytokine receptor interaction.
Function: chemokine activity.

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