Recombinant Mouse Caspase 8
Cat.No. : | Casp8-1645M |
Product Overview : | Recombinant active mouse caspase-8 was expressed in E. coli. |
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- Gene Information
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Cat. No. : | Casp8-1645M |
Description : | Casp8 (also know as FLICE, MASH, Mch5) is a member of the caspase-family of cysteine proteases. Similar to other caspases, casp8 also exists in cells as an inactive proenzyme. During apoptosis procaspase-8 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of casp8 consists of large and small subunits which associate to form the active enzyme. |
Biological Activity : | 5000 units/mg |
Source : | E. coli |
Species : | Mouse |
Form : | Lyophilized powder. |
Appearance : | Lyophilized powder |
Reconstitution : | Reconstitute to 1 unit per µl in PBS containing 15% glycerol. |
Purity : | ≥ 95 % by SDS-PAGE |
Storage : | The lyophilized caspase-8 is stable for 1 year at -70°C. Following reconstitution in PBS, the enzyme should be aliquoted and immediately stored at -70°C. Avoid multiple freeze/thaw cycles as activity might decrease. |
Pathways : | Activation of Pro-Caspase 8; Activation; Alzheimer"s disease; Androgen Receptor Signaling Pathway; Apoptosis; Apoptosis Modulation by HSP70; Apoptotic cleavage of cellular proteins; Apoptotic execution phase; Death Receptor Signalling; Extrinsic Pathway for Apoptosis; Herpes simplex infection; Huntington"s disease; Intrinsic Pathway for Apoptosis; Legionellosis; MAPK signaling pathway |
Gene Name : | Casp8 caspase 8 [ Mus musculus ] |
Official Symbol : | Casp8 |
Synonyms : | Casp8; caspase 8; MACH; Mch5; FLICE; CASP-8; caspase-8; Fas-linked ICE-like protease; Caspase-8; EC 3.4.22.61 |
Gene ID : | 12370 |
mRNA Refseq : | NM_001080126 |
Protein Refseq : | NP_001073595 |
UniProt ID : | O89110 |
Chromosome Location : | 1 B; 1 30.1 cM |
Function : | cysteine-type endopeptidase activity; cysteine-type peptidase activity; hydrolase activity; identical protein binding; peptidase activity; protein binding; tumor necrosis factor receptor binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionStudying the regulatory mechanism of CASP8 protein requires the comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, protein interaction, etc.
The mutation types of CASP8 protein include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.
CASP8 protein has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.
CASP8 protein plays a key role in apoptosis, and its activation can activate downstream effector molecules to trigger programmed cell death.
Mutations in the CASP8 protein can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
By regulating the level of CASP8 protein, some diseases related to apoptosis can be treated, such as by inhibiting its activity or regulating its expression.
Customer Reviews (3)
Write a reviewCASP8 is highly stable.
The reduction of the synthesis cost of this protein leads to the increase of the application.
CASP8 has a high specificity.
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