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Recombinant Mouse Caspase 8

Cat.No. : Casp8-1645M
Product Overview : Recombinant active mouse caspase-8 was expressed in E. coli.
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Cat. No. : Casp8-1645M
Description : Casp8 (also know as FLICE, MASH, Mch5) is a member of the caspase-family of cysteine proteases. Similar to other caspases, casp8 also exists in cells as an inactive proenzyme. During apoptosis procaspase-8 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of casp8 consists of large and small subunits which associate to form the active enzyme.
Biological Activity : 5000 units/mg
Source : E. coli
Species : Mouse
Form : Lyophilized powder.
Appearance : Lyophilized powder
Reconstitution : Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Purity : ≥ 95 % by SDS-PAGE
Storage : The lyophilized caspase-8 is stable for 1 year at -70°C. Following reconstitution in PBS, the enzyme should be aliquoted and immediately stored at -70°C. Avoid multiple freeze/thaw cycles as activity might decrease.
Pathways : Activation of Pro-Caspase 8; Activation; Alzheimer"s disease; Androgen Receptor Signaling Pathway; Apoptosis; Apoptosis Modulation by HSP70; Apoptotic cleavage of cellular proteins; Apoptotic execution phase; Death Receptor Signalling; Extrinsic Pathway for Apoptosis; Herpes simplex infection; Huntington"s disease; Intrinsic Pathway for Apoptosis; Legionellosis; MAPK signaling pathway
Gene Name : Casp8 caspase 8 [ Mus musculus ]
Official Symbol : Casp8
Synonyms : Casp8; caspase 8; MACH; Mch5; FLICE; CASP-8; caspase-8; Fas-linked ICE-like protease; Caspase-8; EC 3.4.22.61
Gene ID : 12370
mRNA Refseq : NM_001080126
Protein Refseq : NP_001073595
UniProt ID : O89110
Chromosome Location : 1 B; 1 30.1 cM
Function : cysteine-type endopeptidase activity; cysteine-type peptidase activity; hydrolase activity; identical protein binding; peptidase activity; protein binding; tumor necrosis factor receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to study the regulatory mechanism of CASP8 protein? 11/28/2022

Studying the regulatory mechanism of CASP8 protein requires the comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, protein interaction, etc.

What are the mutation types of CASP8 protein? 08/06/2022

The mutation types of CASP8 protein include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

What is the relationship between CASP8 protein and other genes or proteins? 06/07/2022

CASP8 protein has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

What is the specific role of CASP8 protein in apoptosis? 06/05/2021

CASP8 protein plays a key role in apoptosis, and its activation can activate downstream effector molecules to trigger programmed cell death.

How to detect and analyze mutations in CASP8 protein? 02/22/2021

Mutations in the CASP8 protein can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

How to treat diseases by regulating the level of CASP8 protein? 12/11/2019

By regulating the level of CASP8 protein, some diseases related to apoptosis can be treated, such as by inhibiting its activity or regulating its expression.

Customer Reviews (3)

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Reviews
04/01/2022

    CASP8 is highly stable.

    03/21/2022

      The reduction of the synthesis cost of this protein leads to the increase of the application.

      04/02/2021

        CASP8 has a high specificity.

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