Recombinant Human Heat Shock 27kDa Protein 1

• Cat.No.: HSPB1-4923H
• Product Overview: Recombinant Human HSPB1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 205 amino acids and have a molecular weight of 22.7 kDa. The protein was purified by proprietary chromatographic techniques.

Specification

• Cat. No.: HSPB1-4923H
• Description: HSPB1 is a protein that in humans is encoded by the HSPB1 gene. HSPB1 is a chaperone of the sHsp (small heat shock protein) group among ubiquitin, α-crystallin, Hsp20 and others. The common functions of sHsps are chaperone activity, thermotolerance, inhibition of apoptosis, regulation of cell development, and cell differentiation. They also take part in signal transduction.
• Biological Activity: Immunoreactivity is confirmed by reaction with monoclonal mouse antibodies against HSPB1.
• Molecular Weight: 22.7 kDa
• Source: E. coli
• Species: Human
• Form: 1 mg/ml solution containing 20 mM Hepes (pH 7.5), 1 mM DTT and 100 mM KCl.
• Appearance: Liquid
• Endotoxin Level: <0.1 ng/μg
• Purity: >98% by SDS-PAGE and HPLC analyses
• Storage: Store at 4 °C for 2-7 days and store at -20 °C for future use. For long-term storage, it is recommended to add a carrier protein (0.1% HAS or BSA). Aviod freeze-thaw cycle.
• Pathways: Amoebiasis; Destabilization of mRNA by AUF1 (hnRNP D0); FAS pathway and Stress induction of HSP regulation; IL-3 Signaling Pathway; IL-6 Signaling Pathway; MAPK signaling pathway; Metabolism of RNA; Metabolism of mRNA; Regulation of mRNA Stability by Proteins that Bind AU-rich Elements; Signaling events mediated by VEGFR1 and VEGFR2; TNF-alpha/NF-kB Signaling Pathway; VEGF signaling pathway

Gene Information

• Gene Name: HSPB1 heat shock 27kDa protein 1 [ Homo sapiens ]
• Official Symbol: HSPB1
• Synonyms: HSPB1; heat shock 27kDa protein 1; CMT2F; HMN2B; HSP27; HSP28; Hsp25; SRP27; HS.76067; DKFZp586P1322; HSPB1; OTTHUMP00000024846; heat shock protein beta-1; HSPB1 heat shock 27kDa protein 1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; Stress-responsive protein 27; heat shock 27kD protein 1; heat shock 27kDa protein 1; heat shock protein beta-1
• Gene ID: 3315
• mRNA Refseq: NM_001540
• Protein Refseq: NP_001531
• MIM: 602195
• UniProt ID: P04792
• Chromosome Location: 7q11.23
• Function: protein binding; protein kinase C delta binding; protein kinase C inhibitor activity; ubiquitin binding