"PIK3R1" Related Products


Recombinant Human Mitogen-Activated Protein Kinase 11

Cat. No.: PIK3R1-4934H
Product Overview: Recombinant human PIK3R1 expressed by Baculovirus is a 86.0 kDa homodimeric protein.
Description: The PIK3R1 comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. p85 modulates the interaction between PIK3R1 and platelet-derived growth factor receptor. Furthermore, estrogen receptor isoform ER-alpha binds in a liganddependent manner to the p85-alpha regulatory subunit of PIK3R1. Stimulation with estrogen increases ER-alphaassociated PIK3R1 activity, leading to the activation of protein kinase B/AKT and endothelial nitric oxide synthase.
Molecular Weight: 86.0 kDa
Source: Baculovirus (Sf9 insect cells)
Species: Human
Form: Recombinant protein in storage buffer (50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 2 mM DTT, 150 mM imidazole, 0.1 mM PMSF, 25 % glycerol.).
Appearance: Liquid
Purity: ≥95% by SDS-PAGE
Storage: Store product frozen at or below -70°C aliquot to avoid repeated thawing and freezing.
Gene Name: PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [ Homo sapiens ]
Official Symbol: PIK3R1
Synonyms: PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); p85; GRB1; p85-ALPHA; phosphatidylinositol 3-kinase regulatory subunit alpha; OTTHUMP00000161918; OTTHUMP00000161919; OTTHUMP00000161920; OTTHUMP00000226152; OTTHUMP00000226159; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase-associated p-85 alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
Gene ID: 5295
mRNA Refseq: NM_181523
Protein Refseq: NP_852664
MIM: 171833
UniProt ID: P27986
Chromosome Location: 5q13.1
Function: 1-phosphatidylinositol binding; ErbB-3 class receptor binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor receptor binding; phosphatidylinositol 3-kinase regulator activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein phosphatase binding

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