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Recombinant Human Peroxisome Proliferator-Activated Receptor Gamma, His-tagged

Cat. No.: PPARG-4935H
Product Overview: Recombinant full-length human PPARG was expressed by baculovirus in E. coli using a N-terminal His tag.
Description: PPARG is a member of the nuclear receptor family of transcription factors, a large and diverse group of proteins that mediate ligand-dependent transcriptional activation and repression. Expression of PPARG is an early and pivotal event in the differentiation of adipocytes. PPARG influences the storage of fatty acids in the adipose tissue and plays a role in adipocyte differentiation. It also binds to DNA as a heterodimer with retinoid X receptor (RXR), activating expression of target genes after binding ligand.
Molecular Weight: 59.2 kDa
Source: E. coli
Species: Human
Form: Sterile-filtered clear solution.
Appearance: Liquid
Reconstitution: PBS 50% glycerol, 0.01% azide.
Purity: ≥95% by SDS-PAGE
Storage: Store, frozen at -20°C. Avoid multiple freeze-thaw cycles.
Gene Name: PPARG peroxisome proliferator-activated receptor gamma [ Homo sapiens ]
Official Symbol: PPARG
Synonyms: PPARG; peroxisome proliferator-activated receptor gamma; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; peroxisome proliferator-activated receptor gamma; PPAR gamma; OTTHUMP00000160185; OTTHUMP00000160186; OTTHUMP00000185030; OTTHUMP00000185032; OTTHUMP00000185034; OTTHUMP00000185036; OTTHUMP00000207750; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1
Gene ID: 5468
mRNA Refseq: NM_005037
Protein Refseq: NP_005028
MIM: 601487
UniProt ID: P37231
Chromosome Location: 3p25
Pathway: Adipogenesis; Calcineurin-regulated NFAT-dependent transcription in lymphocytes; Diabetes pathways; Energy Metabolism; Gene Expression; Generic Transcription Pathway; Huntington"s disease; Noncanonical Wnt signaling pathway; Nuclear Receptors; Nuclear receptors in lipid metabolism and toxicity; Osteoclast differentiation; PPAR signaling pathway; Pathways in cancer; Regulation of retinoblastoma protein; Signaling events mediated by HDAC Class I; Thyroid cancer; Transcriptional Regulation of White Adipocyte Differentiation
Function: DNA binding; activating transcription factor binding; arachidonic acid binding; drug binding; enzyme binding; ligand-dependent nuclear receptor activity; metal ion binding; prostaglandin receptor activity; protein binding; receptor activity; retinoid X receptor binding; contributes_to sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription regulatory region DNA binding; zinc ion binding

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