"BMP2" Related Products

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Recombinant Human Bone Morphogenetic Protein 2

Cat. No.: BMP2-01H
Product Overview: Bone Morphogenetic protein-2 produced inE. coliis a homodimeric, non-glycosylated, Polypeptide chain containing 115 amino acids and having a molecular mass of 26.018 kDa.
Description: Bone morphogenetic protein 2 (BMP-2) is a protein that belongs to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the Hedgehog pathway, TGF-beta signaling pathway, and the Cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition.
Purity: >95% by SDS-PAGE and SEC-HPLC.
Formulation: Lyophilized from a concentrated (1mg/ml) sterile solution containing 10mM sodium citrate pH=3.5.
Specific Activity: BMP-2 is fully biologically active when compared to standard. The ED50 as determined by the cytolysis of MC3T3-E1 cells is less than 50 ng/ml, corresponding to a specific activity of 2.0 x 104IU/mg.
Endotoxin: Less than 0.1ng/µg (1IEU/µg) of Bone Morphogenetic protein-2 .
Reconstitutionon: It is recommended to reconstitute the lyophilized rHuBMP2 in sterile 20mM Acetic acid not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storagee: Lyophilized BMP2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freeze-thaw cycles.
Gene Name: BMP2
Synonyms: BMP2A; BMP-2; Bone morphogenetic protein 2 precursor; bone morphogenetic protein 5; BMP-2A; OTTHUMP00000016650; BMP2.
Gene ID: 650
mRNA Refseq: NM_001200.2
Protein Refseq: NP_001191.1
MIM: 112261
UniProt ID: P12643
Chromosome Location: 20p12
Pathway: BMP signaling pathway; Basal cell carcinoma; Cytokine-cytokine receptor interaction; Hedgehog signaling pathway; TGF-beta signaling pathway
Function: Cytokine activity, Growth factor activity, Specific transcriptional repressor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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