Recombinant Human BMP4 protein
Cat.No. : | BMP4-02H |
Product Overview : | Recombinant Human BMP4 protein was expressed in Escherichia coli. |
- Specification
- Gene Information
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Description : | Bone Morphogenetic Protein 4 is one of the BMPs, some of which belong to the TGF-beta superfamily (BMP2-7). There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation. BMP-4 is expressed in the lung and lower levels seen in the kidney. It also presents in normal and neoplastic prostate tissues, and prostate cancer cell lines. It regulates the formation of teeth, limbs and bone from mesoderm. Furthermore it also plays a role in fracture repair. BMP-4 signals through tetrameric complexes composed of type I and type II receptors and regulates it function by interaction with multiple proteins and glycosaminoglycans. The human BMP-4 shares 98 % sequence indentity with mouse BMP-4. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. |
Source : | E.coli |
Species : | Human |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in 50 mM Na2CO3, 5 mM DTT, pH 11.0. |
Molecular Mass : | Approximately 13.3 kDa, a monomeric, non-glycosylated polypeptide chain containing 117 amino acids. |
Protein length : | 117 |
AA Sequence : | MSPKHHSQRARKKNKNCRRHSLYVD FSDVGWNDWIVAPPGYQAFYCHGDC PFPLADHLNSTNHAIVQTLVNSVNS SIPKACCVPTELSAISMLYLDEYDK VVLKNYQEMVVEGCGCR |
Endotoxin : | Less than 1 EU/µg of rHuBMP-4 as determined by LAL method. |
Purity : | >95% by SDS-PAGE and HPLC analysis. |
Applications : | Molecular standard (Western, ELISA) in studying secreted BMP-4; Preparing antibodies for BMP-4 monomer; Molecule standard in detecting secreted BMP-4 in reduced SDS-PAGE. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | BMP4 |
Official Symbol : | BMP4 |
Synonyms : | BMP4; bone morphogenetic protein 4; BMP2B; BMP-4; BMP-2B; bone morphogenetic protein 2B; ZYME; OFC11; BMP2B1; MCOPS6; |
Gene ID : | 652 |
mRNA Refseq : | NM_001202 |
Protein Refseq : | NP_001193 |
MIM : | 112262 |
UniProt ID : | P12644 |
Products Types
◆ Recombinant Protein | ||
BMP4-013H | Active Recombinant Human BMP4 Protein | +Inquiry |
Bmp4-14M | Recombinant Active Mouse BMP4 Protein, His-tagged(C-ter) | +Inquiry |
BMP4-02P | Recombinant Pig BMP4 Protein (Arg227-Cys408), C-His tagged, Animal-free, Carrier-free | +Inquiry |
Bmp4-323M | Recombinant Mouse Bmp4 Protein, His-tagged | +Inquiry |
bmp4-322Z | Recombinant Zebrafish bmp4 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
BMP4-8431HCL | Recombinant Human BMP4 293 Cell Lysate | +Inquiry |
BMP4-8432HCL | Recombinant Human BMP4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionBMP4 can be used in spinal fusion surgery to stimulate bone growth and fuse vertebrae together, which can alleviate back pain and stabilize the spine.
Mutations in BMP4 or its receptors can lead to congenital disorders, such as orofacial clefts and heart defects.
Yes, there are ongoing trials exploring the use of BMP4 in regenerative medicine for conditions like osteoarthritis and tendon injuries.
Yes, some risks include excessive bone growth, swelling, and inflammation at the application site. These complications can be carefully managed by healthcare providers.
Yes, BMP4 can be used to aid in tissue regeneration in cosmetic procedures, such as in the reconstruction of facial bone defects or enhancement of soft tissue volume.
Customer Reviews (3)
Write a reviewThe BMP4 protein is a valuable resource for researchers due to its high quality and its ability to meet specific experimental needs.
the manufacturer's technical support team can offer prompt assistance in case any issues arise during the handling or application of the BMP4 protein.
The manufacturer's support can play a crucial role in assisting researchers throughout their trials.
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