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Recombinant Human BMP4 protein

Cat.No. : BMP4-02H
Product Overview : Recombinant Human BMP4 protein was expressed in Escherichia coli.
  • Specification
  • Gene Information
  • Related Products
Description : Bone Morphogenetic Protein 4 is one of the BMPs, some of which belong to the TGF-beta superfamily (BMP2-7). There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation. BMP-4 is expressed in the lung and lower levels seen in the kidney. It also presents in normal and neoplastic prostate tissues, and prostate cancer cell lines. It regulates the formation of teeth, limbs and bone from mesoderm. Furthermore it also plays a role in fracture repair. BMP-4 signals through tetrameric complexes composed of type I and type II receptors and regulates it function by interaction with multiple proteins and glycosaminoglycans. The human BMP-4 shares 98 % sequence indentity with mouse BMP-4. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva.
Source : E.coli
Species : Human
Form : Lyophilized from a 0.2μm filtered concentrated solution in 50 mM Na2CO3, 5 mM DTT, pH 11.0.
Molecular Mass : Approximately 13.3 kDa, a monomeric, non-glycosylated polypeptide chain containing 117 amino acids.
Protein length : 117
AA Sequence : MSPKHHSQRARKKNKNCRRHSLYVD FSDVGWNDWIVAPPGYQAFYCHGDC PFPLADHLNSTNHAIVQTLVNSVNS SIPKACCVPTELSAISMLYLDEYDK VVLKNYQEMVVEGCGCR
Endotoxin : Less than 1 EU/µg of rHuBMP-4 as determined by LAL method.
Purity : >95% by SDS-PAGE and HPLC analysis.
Applications : Molecular standard (Western, ELISA) in studying secreted BMP-4; Preparing antibodies for BMP-4 monomer; Molecule standard in detecting secreted BMP-4 in reduced SDS-PAGE.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : BMP4
Official Symbol : BMP4
Synonyms : BMP4; bone morphogenetic protein 4; BMP2B; BMP-4; BMP-2B; bone morphogenetic protein 2B; ZYME; OFC11; BMP2B1; MCOPS6;
Gene ID : 652
mRNA Refseq : NM_001202
Protein Refseq : NP_001193
MIM : 112262
UniProt ID : P12644

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is BMP4 applied in spinal fusion surgery? 03/30/2022

BMP4 can be used in spinal fusion surgery to stimulate bone growth and fuse vertebrae together, which can alleviate back pain and stabilize the spine.

Are there any genetic disorders related to BMP4? 07/03/2020

Mutations in BMP4 or its receptors can lead to congenital disorders, such as orofacial clefts and heart defects.

Are there ongoing clinical trials involving BMP4 in regenerative medicine? 07/12/2019

Yes, there are ongoing trials exploring the use of BMP4 in regenerative medicine for conditions like osteoarthritis and tendon injuries.

Are there any potential risks or side effects associated with the clinical use of BMP4? 06/11/2018

Yes, some risks include excessive bone growth, swelling, and inflammation at the application site. These complications can be carefully managed by healthcare providers.

Can BMP4 be used in cosmetic surgery? 02/10/2017

Yes, BMP4 can be used to aid in tissue regeneration in cosmetic procedures, such as in the reconstruction of facial bone defects or enhancement of soft tissue volume.

Customer Reviews (3)

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11/22/2020

    The BMP4 protein is a valuable resource for researchers due to its high quality and its ability to meet specific experimental needs.

    08/26/2020

      the manufacturer's technical support team can offer prompt assistance in case any issues arise during the handling or application of the BMP4 protein.

      06/05/2018

        The manufacturer's support can play a crucial role in assisting researchers throughout their trials.

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