Recombinant Human CHK1 Checkpoint Homolog (S. pombe), GST-tagged

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Recombinant Human CHK1 Checkpoint Homolog (S. pombe), GST-tagged

CHEK1 Related Products

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Cat. No. : CHEK1-4838H
Product Overview : Recombinant full-length human CHEK1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Description : CHEK1 is a 56 kd serine/threonine protein kinase that was originally identified in fission yeast to play a role in activation of the DNA damage checkpoint in the G2 phase of the cell cycle. CHEK1 appears to function downstream of several of the known fission yeast checkpoint gene products, including that encoded by rad3+, a gene with sequence similarity to the ATM gene mutated in patients with ataxia telangiectasia.
Applications : Kinase Assay; Western Blot
Molecular Weight : 82 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 Mm EDTA, 0.1 mM PMSF, 25 % glycerol.
Specific Activity : 214 nmol/min/mg
Purity : > 95 %
Concentration : 0.1 ug/ul
Sequences : Full-lengt h
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Activation of ATR in response to replication stress; Cell cycle; p53 signaling pathway; Cell Cycle Checkpoints; IL-3 Signaling Pathway; HTLV-I infection; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
PDBrendering based on 1ia8. :

Gene Name : CHEK1 CHK1 checkpoint homolog (S. pombe) [ Homo sapiens ]
Official Symbol : CHEK1
Synonyms : CHEK1; CHK1 checkpoint homolog (S. pombe); CHK1; CHK1 (checkpoint, S. pombe) homolog; Serine/threonine-protein kinase Chk1; EC 2.7.11.1; serine/threonine-protein kinase Chk1; OTTHUMP00000231300; OTTHUMP00000231301; OTTHUMP00000231306; OTTHUMP00000231307; OTTHUMP00000231309; Checkpoint, S. pombe, homolog of, 1
Gene ID : 1111
mRNA Refseq : NM_001114121
Protein Refseq : NP_001107593
MIM : 603078
UniProt ID : O14757
Chromosome Location : 11q24.2
Function : ATP binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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