Recombinant Human CDC-Like Kinase 2, GST-tagged

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Recombinant Human CDC-Like Kinase 2, GST-tagged

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Cat. No. : CLK2-1005H
Product Overview : Recombinant human CLK2 (137-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : CDC-like kinase 2 (CLK2) a family of autophosphorylating kinases termed CLK (CDC2/CDC28-like kinases) was shown to phosphorylate SR proteins and to influence alternative splicing in overexpression systems. Recent findings demonstrated that the CLK kinases activate PTP-1B family members, and this phosphatase may be an important cellular target for CLK action. Mutations in the clk-2 proteins affect organismal features such as development, behavior, reproduction, and aging as well as cellular features such as the cell cycle, apoptosis, the DNA replication checkpoint, and telomere length.
Applications : Kinase Assay; Western Blot
Molecular Weight : 68 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM EDTA, 0.1 mM PMSF, 25 % glycerol.
Specific Activity : 52 nmol/min/mg
Purity : > 80 %
Concentration : 0.1 ug/ul
Sequences : 137-end
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : mRNA processing
Gene Name : CLK2 CDC-like kinase 2 [ Homo sapiens ]
Official Symbol : CLK2
Synonyms : CLK2; CDC-like kinase 2; hCLK2; MGC61500; dual specificity protein kinase CLK2; CLK kinase; OTTHUMP00000034063; OTTHUMP00000034064; THUMP00000034065; clk2; Dual specificity protein kinase CLK2; EC 2.7.12.1
Gene ID : 1196
mRNA Refseq : NM_003993
Protein Refseq : NP_003984
MIM : 602989
UniProt ID : P49760
Chromosome Location : 1q21
Function : ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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