"HDAC8" Related Products


Recombinant Human Histone Deacetylase 8, His-tagged

Cat. No.: HDAC8-1595H
Product Overview: Full-length recombinant human HDAC8 was expressed by baculovirus in Sf9 insect cells using a C-terminal His tag.
Description: HDAC8 or Histone deacetylase 8 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. The protein encoded by this gene belongs to class I of the histone deacetylase family that catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors.
Applications: HDAC Assay; Western Blot
Molecular Weight: 47 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50 mM MOPS, PH 7.0, 300 mM NaCI, 150 mM imidazole, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Purity: >90%
Concentration: 0.05 ug/ul
Specific Activity: 1400 RLU/min/ng
Sequences: Full length
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class I
Gene Name: HDAC8 histone deacetylase 8 [ Homo sapiens ]
Official Symbol: HDAC8
Synonyms: HDAC8; histone deacetylase 8; HD8; RPD3; CDA07; HDACL1; histone deacetylase 8; OTTHUMP00000023539; OTTHUMP00000023540; OTTHUMP00000023541; OTTHUMP00000023542; OTTHUMP00000023543; OTTHUMP00000023544; OTTHUMP00000023545; OTTHUMP00000023546; OTTHUMP00000023549; histone deacetylase-like 1
Gene ID: 55869
mRNA Refseq: NM_001166418
Protein Refseq: NP_001159890
MIM: 300269
UniProt ID: Q9BY41
Chromosome Location: Xq13
Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity (H3-K16 specific); hydrolase activity; transcription factor binding; metal ion binding; histone deacetylase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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