Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 10, GST-Tagged

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Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 10, GST-Tagged

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Cat. No. : MAP3K10-1038H
Product Overview : Recombinant human MAP3K10 (1-446) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : MAP3K10 or mixed-lineage kinase 2 is a member of the serine/threonine kinase family, which activates MAPK8 JNK and MKK4/SEK1. MAP3K10 itself can be phoshorylated, and activated by JNK kinases. MAP3K10 is also known as mitogen-activated protein kinase kinase kinase 10 (MAP3K10). MAP3K10 functions preferentially on the JNK signaling pathway which is involved in nerve growth factor (NGF) induced neuronal apoptosis. MAP3K10 was isolated as a cDNA fragment from MKN28 gastric cancer cell library using degenerate PCR. MAP3K10 is highly expressed in brain, skeletal muscle, and testis.
Applications : Kinase Assay, Western Blot
Molecular Weight : 76 kDa
Expression System : Sf9 insect cells using baculovirus.
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10mM glutathione, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Specific Activity : 948 nmol/min/mg
Purity : > 85 %
Concentration : 0.1 ug/ul
Sequences : 1-446
Storage : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Insulin Signaling; p38 MAPK signaling pathwa
Gene Name : MAP3K10 mitogen-activated protein kinase kinase kinase 10 [ Homo sapiens ]
Official Symbol : MAP3K10
Synonyms : MAP3K10; MST; MLK2; MEKK10; mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; Protein kinase MST; EC 2.7.11.25; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; EC 2.7.11
Gene ID : 4294
mRNA Refseq : NM_002446
Protein Refseq : NP_002437
MIM : 600137
UniProt ID : Q02779
Chromosome Location : 19q13.2
Function : ATP binding; JUN kinase kinase kinase activity; MAP kinase kinase activity; nucleotide binding; protein homo- dimerization activity; protein serine/threonine kinase activity; protein tyrosine kinase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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