Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 11, GST-Tagged

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Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 11, GST-Tagged

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Cat. No. : MAP3K11-1039H
Product Overview : Recombinant human MAP3K11 (1-488) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : MAP3K11 or Mixed-Lineage Kinase 3 is a mitogen-activated protein kinase kinase kinase capable of preferentially activating MAPK8/JNK kinase and functions as a positive regulator of JNK signaling pathway. MAP3K11 can directly phosphorylate and activate IkappaB kinase α and β, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. MAP3K11 is a signal-integrating kinase with conventional MAP3K catalytic activity and additional noncatalytic functions that contribute to RAF/ERK signalling.
Applications : Kinase Assay, Western Blot
Molecular Weight : 83 kDa
Expression System : Sf9 insect cells using baculovirus.
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10mM glutathione, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Specific Activity : 9.5 nmol/min/mg
Purity : > 85 %
Concentration : 0.1 ug/ul
Sequences : 1-488
Storage : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : CDC42 signaling events; IFN-gamma pathway; Insulin Signaling; MAPK signaling pathway; RAC1 signaling pathway; Reelin signaling pathway; superpathway of gluconate degradation
Gene Name : MAP3K11 mitogen-activated protein kinase kinase kinase 11 [ Homo sapiens ]
Official Symbol : MAP3K11
Synonyms : MAP3K11; MLK3; MGC17114; PTK1; SPRK; MLK-3; MEKK11; mitogen-activated protein kinase kinase kinase 11; mixed lineage kinase 3; protein-tyrosine kinase PTK1; SH3 domain-containing proline-rich kinase; OTTHUMP00000233268; src-homology 3 domain-containing proline-rich kinase; OTTHUMP00000233249
Gene ID : 4296
mRNA Refseq : NM_002419
Protein Refseq : NP_002410
MIM : 600050
UniProt ID : Q16584
Chromosome Location : 11q13.1-q13.3
Function : ATP binding; JUN kinase kinase kinase activity; Rac GTPase binding; identical protein binding; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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