Recombinant Human Sirtuin 2, GST-tagged
Cat.No. : | SIRT2-4876H |
Product Overview : | Full-length recombinant human SIRT2 was expressed in E. coli cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | SIRT2-4876H |
Description : | SIRT2 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT2 being a member of class I. Inhibition of SIRT2 can lead to neuroprotection in cellular and invertebrate models of Huntington" s disease. Huntington"s disease is characterized by increased sterol synthesis in neuronal cells and this process is reversed by SIRT2 inhibition. |
Applications : | Western Blot |
Molecular Weight : | 64 kDa |
Expression System : | E. coli |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25 % glycerol. |
Purity : | > 85 % |
Concentration : | 0.2 ug/ul |
Sequences : | Full-length |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class III |
Gene Name : | SIRT2 sirtuin 2 [ Homo sapiens ] |
Official Symbol : | SIRT2 |
Synonyms : | SIRT2; sirtuin 2; SIR2; SIR2L; SIR2L2; FLJ35621; FLJ37491; NAD-dependent deacetylase sirtuin-2; sirtuin type 2; OTTHUMP00000197460; OTTHUMP00000197461; OTTHUMP00000197465; SIR2-like protein 2; sir2-related protein type 2; silent information regulator 2; EC 3.5.1.-; sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 2 |
Gene ID : | 22933 |
mRNA Refseq : | NM_012237 |
Protein Refseq : | NP_036369 |
MIM : | 604480 |
UniProt ID : | Q8IXJ6 |
Chromosome Location : | 19q13 |
Function : | NAD binding; NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; histone acetyltransferase binding; histone deacetylase binding; hydrolase activity; metal ion binding; transcription factor binding; tubulin deacetylase activity; ubiquitin binding; zinc ion binding; protein binding; protein deacetylase activity |
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◆ Lysates | ||
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◆ Assay kits | ||
Kit-2026 | SIRT2 Direct Fluorescent Screening Assay Kit | +Inquiry |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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