"SIRT2" Related Products

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Recombinant Human Sirtuin 2, GST-tagged

Cat. No.: SIRT2-4876H
Product Overview: Full-length recombinant human SIRT2 was expressed in E. coli cells using an N-terminal GST tag.
Description: SIRT2 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT2 being a member of class I. Inhibition of SIRT2 can lead to neuroprotection in cellular and invertebrate models of Huntington" s disease. Huntington"s disease is characterized by increased sterol synthesis in neuronal cells and this process is reversed by SIRT2 inhibition.
Applications: Western Blot
Molecular Weight: 64 kDa
Expression System: E. coli
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25 % glycerol.
Purity: > 85 %
Concentration: 0.2 ug/ul
Sequences: Full-length
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class III
Gene Name: SIRT2 sirtuin 2 [ Homo sapiens ]
Official Symbol: SIRT2
Synonyms: SIRT2; sirtuin 2; SIR2; SIR2L; SIR2L2; FLJ35621; FLJ37491; NAD-dependent deacetylase sirtuin-2; sirtuin type 2; OTTHUMP00000197460; OTTHUMP00000197461; OTTHUMP00000197465; SIR2-like protein 2; sir2-related protein type 2; silent information regulator 2; EC 3.5.1.-; sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 2
Gene ID: 22933
mRNA Refseq: NM_012237
Protein Refseq: NP_036369
MIM: 604480
UniProt ID: Q8IXJ6
Chromosome Location: 19q13
Function: NAD binding; NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; histone acetyltransferase binding; histone deacetylase binding; hydrolase activity; metal ion binding; transcription factor binding; tubulin deacetylase activity; ubiquitin binding; zinc ion binding; protein binding; protein deacetylase activity

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