Recombinant Human Sirtuin 6, GST-tagged SIRT6-4883H

Recombinant Human Sirtuin 6, GST-tagged

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Cat. No. :	SIRT6-4883H
Product Overview :	Full-length recombinant human SIRT6 was expressed in E. coli cells using an N-terminal GST tag.
Description :	SIRT6 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT6 being a member of class IV. Human SIRT6 protein is a NAD (+)-dependent histone H3 lysine-9 deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence.
Applications :	Western Blot
Molecular Weight :	66 kDa
Expression System :	E. coli
Species :	Human
Form :	Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25 % glycerol.
Purity :	> 85 %
Concentration :	0.2 ug/ul
Sequences :	Full-lengt h
Storage :	Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways :	Signaling events mediated by HDAC Class I

Gene Name :	SIRT6 sirtuin 6 [ Homo sapiens ]
Official Symbol :	SIRT6
Synonyms :	SIRT6; sirtuin 6; SIR2L6; NAD-dependent deacetylase sirtuin-6; sirtuin type 6; SIR2-like protein 6; sir2-related protein type 6; EC 2.4.2.31; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6
Gene ID :	51548
mRNA Refseq :	NM_016539
Protein Refseq :	NP_057623
MIM :	606211
UniProt ID :	Q8N6T7
Chromosome Location :	19p13.3
Function :	NAD binding; NAD (P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; hydrolase activity; metal ion binding; protein binding; transferase activity, transferring glycosyl groups; zinc ion binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific)